HDAC5 and SIK3

Number of citations of the paper that reports this interaction (PubMedID 23393134)
36

Data Source:
BioGRID (enzymatic study)

		HDAC5	SIK3
Description		histone deacetylase 5	SIK family kinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Speck	Cytoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Chromatin Binding Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Metal Ion Binding Repressing Transcription Factor Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Tau-protein Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Chromatin Silencing Protein Deacetylation Inflammatory Response Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Response To Activity Histone Deacetylation Neuron Differentiation B Cell Differentiation Cellular Response To Insulin Stimulus Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Cocaine Regulation Of Protein Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Histone H3 Deacetylation Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Histone H3-K9 Acetylation	Microtubule Cytoskeleton Organization Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs		Belinostat Panobinostat
Diseases
GWAS		Bipolar disorder ( 31043756) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Heel bone mineral density ( 30598549 28869591)	Allergic rhinitis ( 30013184) Blood protein levels ( 28240269) Delirium ( 29631748) Eosinophil counts ( 27863252) Eosinophil percentage of white cells ( 27863252) HDL cholesterol ( 31170924 24886709) Hearing function ( 25060954) Medication use (thyroid preparations) ( 31015401) Metabolic syndrome ( 30382898) Non-accommodative esotropia ( 30098192) Response to Vitamin E supplementation ( 22437554) Sum eosinophil basophil counts ( 27863252) Triglyceride levels ( 29615537) Triglycerides ( 24886709)
Interacting Genes		60 interacting genes: ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 H3C1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 RFXANK RUNX3 SFN SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SUV39H1 TAB2 UBC UBE2I YWHAB YWHAE YWHAQ ZBTB16	7 interacting genes: ATP5MG CRTC2 HDAC5 PRKACA TRAF1 TRIP6 YWHAZ
Entrez ID		10014	23387
HPRD ID		09246	11121
Ensembl ID		ENSG00000108840	ENSG00000160584
Uniprot IDs		Q9UQL6	A1A5A9 Q9Y2K2
PDB IDs		5UWI
Enriched GO Terms of Interacting Partners?
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