MARK3 and PNPLA2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MARK3	PNPLA2
Description		microtubule affinity regulating kinase 3	patatin like phospholipase domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Dendrite Extracellular Exosome	Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Tau Protein Binding Tau-protein Kinase Activity	Triglyceride Lipase Activity
	Biological Process	MAPK Cascade Microtubule Cytoskeleton Organization Protein Phosphorylation Peptidyl-serine Phosphorylation Positive Regulation Of Protein Binding Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Peptidyl-serine Autophosphorylation	Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Droplet Organization Acylglycerol Acyl-chain Remodeling Post-translational Protein Modification Cellular Protein Metabolic Process Lipid Homeostasis
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	Acyl chain remodeling of DAG and TAG Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Body mass index ( 26426971) Coronary artery disease ( 29212778) Femoral neck bone mineral density ( 22504420) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Mean corpuscular hemoglobin ( 27863252) Monocyte count ( 29403010 27863252) Optic disc size ( 31809533) Systolic blood pressure ( 30224653 30578418) Type 2 diabetes ( 30297969)	Body fat distribution (arm fat ratio) ( 30664634) Keratoconus ( 31855235)
Interacting Genes		35 interacting genes: ANKRD7 ARHGEF2 ASB13 ATP6V0C CDC25C CDC42BPB CHGB CLASP1 CLASP2 CPSF4 DYNLL1 FANCF FBXO7 HDAC7 HMOX2 KSR1 MAP2 MAPT MITF NOL11 PKP2 PMPCB PNPLA2 PRKCQ RCOR3 RECQL SAAL1 SFN SLC27A4 TCEA2 TTR VPS11 YWHAG YWHAQ YWHAZ	10 interacting genes: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2
Entrez ID		4140	57104
HPRD ID		04058	11443
Ensembl ID		ENSG00000075413	ENSG00000177666
Uniprot IDs		P27448 Q86U11	Q96AD5
PDB IDs		2QNJ 3FE3
Enriched GO Terms of Interacting Partners?
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