MARK3 and CPSF4

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		MARK3	CPSF4
Description		microtubule affinity regulating kinase 3	cleavage and polyadenylation specific factor 4
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Dendrite Extracellular Exosome	Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Tau Protein Binding Tau-protein Kinase Activity	RNA Binding Protein Binding Zinc Ion Binding
	Biological Process	MAPK Cascade Microtubule Cytoskeleton Organization Protein Phosphorylation Peptidyl-serine Phosphorylation Positive Regulation Of Protein Binding Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Peptidyl-serine Autophosphorylation	MRNA Splicing, Via Spliceosome Termination Of RNA Polymerase II Transcription TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Export From Nucleus MRNA 3'-end Processing Modification By Virus Of Host MRNA Processing Pre-mRNA Cleavage Required For Polyadenylation
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	Transport of Mature mRNA Derived from an Intronless Transcript Inhibition of Host mRNA Processing and RNA Silencing tRNA processing in the nucleus mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Body mass index ( 26426971) Coronary artery disease ( 29212778) Femoral neck bone mineral density ( 22504420) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Mean corpuscular hemoglobin ( 27863252) Monocyte count ( 29403010 27863252) Optic disc size ( 31809533) Systolic blood pressure ( 30224653 30578418) Type 2 diabetes ( 30297969)	Diffuse cutaneous systemic sclerosis ( 29293537) Facial emotion recognition (sad faces) ( 28608620) Serum metabolite levels ( 23093944) Tacrolimus trough concentration in kidney transplant patients ( 29160300)
Interacting Genes		35 interacting genes: ANKRD7 ARHGEF2 ASB13 ATP6V0C CDC25C CDC42BPB CHGB CLASP1 CLASP2 CPSF4 DYNLL1 FANCF FBXO7 HDAC7 HMOX2 KSR1 MAP2 MAPT MITF NOL11 PKP2 PMPCB PNPLA2 PRKCQ RCOR3 RECQL SAAL1 SFN SLC27A4 TCEA2 TTR VPS11 YWHAG YWHAQ YWHAZ	5 interacting genes: CREBBP FIP1L1 MARK3 MEOX2 SLC12A9
Entrez ID		4140	10898
HPRD ID		04058	04338
Ensembl ID		ENSG00000075413	ENSG00000160917
Uniprot IDs		P27448 Q86U11	B7Z7B0 O95639
PDB IDs		2QNJ 3FE3	2D9N 2RHK 6DNH 6FBS 6FUW 6URG 6URO
Enriched GO Terms of Interacting Partners?
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