MARK3 and RCOR3

		MARK3	RCOR3
Description		microtubule affinity regulating kinase 3	REST corepressor 3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Dendrite Extracellular Exosome	Nucleus Transcriptional Repressor Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Tau Protein Binding Tau-protein Kinase Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Transcription Regulatory Region DNA Binding
	Biological Process	MAPK Cascade Microtubule Cytoskeleton Organization Protein Phosphorylation Peptidyl-serine Phosphorylation Positive Regulation Of Protein Binding Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Peptidyl-serine Autophosphorylation	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Body mass index ( 26426971) Coronary artery disease ( 29212778) Femoral neck bone mineral density ( 22504420) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Mean corpuscular hemoglobin ( 27863252) Monocyte count ( 29403010 27863252) Optic disc size ( 31809533) Systolic blood pressure ( 30224653 30578418) Type 2 diabetes ( 30297969)
Interacting Genes		35 interacting genes: ANKRD7 ARHGEF2 ASB13 ATP6V0C CDC25C CDC42BPB CHGB CLASP1 CLASP2 CPSF4 DYNLL1 FANCF FBXO7 HDAC7 HMOX2 KSR1 MAP2 MAPT MITF NOL11 PKP2 PMPCB PNPLA2 PRKCQ RCOR3 RECQL SAAL1 SFN SLC27A4 TCEA2 TTR VPS11 YWHAG YWHAQ YWHAZ	32 interacting genes: APP CCDC102B CDR2 CEP55 CEP70 GOLGA2 GSE1 IKZF3 KDM1A KRT15 KRT31 KRT40 LCA5 LUZP4 LZTS2 MAGEA6 MARK3 MID2 MIPOL1 NECAB2 NINL PHF21B PRDM14 SUMO2 TFIP11 TRAF2 TRIM27 TRIM42 TRIM54 TSGA10 TXLNA YWHAQ
Entrez ID		4140	55758
HPRD ID		04058	08338
Ensembl ID		ENSG00000075413	ENSG00000117625
Uniprot IDs		P27448 Q86U11	Q9P2K3
PDB IDs		2QNJ 3FE3	4CZZ
Enriched GO Terms of Interacting Partners?
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