ITGA4 and VCAN

Number of citations of the paper that reports this interaction (PubMedID 11083865)
55

Data Source:
HPRD (in vitro)

		ITGA4	VCAN
Description		integrin subunit alpha 4	versican
Image			No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Focal Adhesion Cell Surface Membrane Growth Cone Protein-containing Complex Integrin Alpha4-beta7 Complex Neuronal Cell Body Extracellular Exosome	Photoreceptor Outer Segment Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Membrane Extracellular Matrix Interphotoreceptor Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Fibronectin Binding Protein Binding Coreceptor Activity C-X3-C Chemokine Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding Protein Antigen Binding	Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding
	Biological Process	Cell-matrix Adhesion Involved In Ameboidal Cell Migration Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway B Cell Differentiation Extracellular Matrix Organization Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Receptor Clustering Regulation Of Immune Response Leukocyte Migration Leukocyte Tethering Or Rolling Diapedesis Axonogenesis Involved In Innervation Cellular Response To Cytokine Stimulus Negative Regulation Of Protein Homodimerization Activity Cell-cell Adhesion In Response To Extracellular Stimulus Positive Regulation Of Leukocyte Tethering Or Rolling Cellular Response To Amyloid-beta Positive Regulation Of Vascular Endothelial Cell Proliferation Neuron Projection Extension Clathrin-dependent Extracellular Exosome Endocytosis Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T Cell Migration	Skeletal System Development Osteoblast Differentiation Cell Adhesion Multicellular Organism Development Central Nervous System Development Cell Recognition Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions RUNX3 Regulates Immune Response and Cell Migration	A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation
Drugs		Natalizumab ATL1102 CDP323 R1295 R411 Tinzaparin Vedolizumab	Hyaluronic acid
Diseases			Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
GWAS		Celiac disease ( 22057235 20190752) Crohn's disease ( 28067908) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908) Lymphocyte percentage of white cells ( 27863252) Monocyte count ( 23314186 28193307 25096241 29403010 27863252) Monocyte percentage of white cells ( 27863252) Monocyte-lymphocyte ratio ( 28193307) Multiple sclerosis ( 24076602) Neurofibrillary tangles ( 25188341) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Ulcerative colitis ( 28067908) White blood cell count ( 29403010 21738480) White blood cell count (basophil) ( 29403010) White blood cell count (monocyte) ( 28158719) White blood cell types ( 21738478)	Appendicular lean mass ( 28724990) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diisocyanate-induced asthma ( 25918132) Gastroesophageal reflux disease ( 31527586) Joint mobility (Beighton score) ( 27182965) Laryngeal squamous cell carcinoma ( 25194280) Lean body mass ( 28724990) Major depressive disorder ( 20516156) Optic disc size ( 31809533) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter hyperintensity volume ( 29752348) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)
Interacting Genes		16 interacting genes: ADAM28 CD81 CD82 EED FN1 ICAM4 ITGB1 ITGB7 LGALS8 LPXN MADCAM1 PRKACA PRKAR1A PXN TGFB1I1 VCAN	22 interacting genes: ADAMTS1 CCL2 CCL20 CCL21 CCL5 CCL8 CD44 CXCL10 CXCL12 FBLN1 FBLN2 FBN1 HAPLN1 ITGA4 ITGB1 PF4 PLA2G2A SELL SELP SELPLG TNR XCL1
Entrez ID		3676	1462
HPRD ID		01894	00340
Ensembl ID		ENSG00000115232	ENSG00000038427
Uniprot IDs		P13612	A0A024RAL1 A0A024RAP3 A0A024RAQ9 P13611 Q59FG9 Q6MZK8 Q86W61
PDB IDs		3V4P 3V4V 4HKC 5C7Z 5FPI
Enriched GO Terms of Interacting Partners?
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