VCAN and CCL21

Number of citations of the paper that reports this interaction (PubMedID 11083865)
55

Data Source:
HPRD (in vitro)

		VCAN	CCL21
Description		versican	C-C motif chemokine ligand 21
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Membrane Extracellular Matrix Interphotoreceptor Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Cell
	Molecular Function	Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding	Protein Binding Chemokine Activity CCR7 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Skeletal System Development Osteoblast Differentiation Cell Adhesion Multicellular Organism Development Central Nervous System Development Cell Recognition Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Post-translational Protein Modification Cellular Protein Metabolic Process	Establishment Of T Cell Polarity Immunological Synapse Formation Positive Regulation Of Cell-matrix Adhesion Dendritic Cell Chemotaxis Monocyte Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of T Cell Chemotaxis Neutrophil Chemotaxis Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly T Cell Costimulation Ruffle Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Response To Prostaglandin E Mesangial Cell-matrix Adhesion Chemokine (C-C Motif) Ligand 21 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Lymphocyte Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Filopodium Assembly Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis Activation Of GTPase Activity Dendritic Cell Dendrite Assembly Negative Regulation Of Leukocyte Tethering Or Rolling Cellular Response To Chemokine Positive Regulation Of Cell Motility Positive Regulation Of T Cell Migration Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Negative Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Hyaluronic acid
Diseases		Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
GWAS		Appendicular lean mass ( 28724990) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diisocyanate-induced asthma ( 25918132) Gastroesophageal reflux disease ( 31527586) Joint mobility (Beighton score) ( 27182965) Laryngeal squamous cell carcinoma ( 25194280) Lean body mass ( 28724990) Major depressive disorder ( 20516156) Optic disc size ( 31809533) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter hyperintensity volume ( 29752348) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)	Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Rheumatoid arthritis ( 30423114 18794853 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		22 interacting genes: ADAMTS1 CCL2 CCL20 CCL21 CCL5 CCL8 CD44 CXCL10 CXCL12 FBLN1 FBLN2 FBN1 HAPLN1 ITGA4 ITGB1 PF4 PLA2G2A SELL SELP SELPLG TNR XCL1	10 interacting genes: ACKR2 ACKR4 CCR7 CTSD CXCL13 GOT2 IGFBP7 LRRK1 UBQLN4 VCAN
Entrez ID		1462	6366
HPRD ID		00340	04113
Ensembl ID		ENSG00000038427	ENSG00000137077
Uniprot IDs		A0A024RAL1 A0A024RAP3 A0A024RAQ9 P13611 Q59FG9 Q6MZK8 Q86W61	O00585
PDB IDs			2L4N 5EKI
Enriched GO Terms of Interacting Partners?
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