ITGA4 and MADCAM1

Number of citations of the paper that reports this interaction (PubMedID 10702270)
4

Data Source:
HPRD (in vitro)

		ITGA4	MADCAM1
Description		integrin subunit alpha 4	mucosal vascular addressin cell adhesion molecule 1
Image
GO Annotations	Cellular Component	Cell Plasma Membrane Focal Adhesion Cell Surface Membrane Growth Cone Protein-containing Complex Integrin Alpha4-beta7 Complex Neuronal Cell Body Extracellular Exosome	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Fibronectin Binding Protein Binding Coreceptor Activity C-X3-C Chemokine Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding Protein Antigen Binding	Integrin Binding Involved In Cell-matrix Adhesion
	Biological Process	Cell-matrix Adhesion Involved In Ameboidal Cell Migration Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway B Cell Differentiation Extracellular Matrix Organization Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Receptor Clustering Regulation Of Immune Response Leukocyte Migration Leukocyte Tethering Or Rolling Diapedesis Axonogenesis Involved In Innervation Cellular Response To Cytokine Stimulus Negative Regulation Of Protein Homodimerization Activity Cell-cell Adhesion In Response To Extracellular Stimulus Positive Regulation Of Leukocyte Tethering Or Rolling Cellular Response To Amyloid-beta Positive Regulation Of Vascular Endothelial Cell Proliferation Neuron Projection Extension Clathrin-dependent Extracellular Exosome Endocytosis Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T Cell Migration	Positive Regulation Of Leukocyte Migration Immune Response Cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Extracellular Matrix Organization Heterotypic Cell-cell Adhesion Receptor Clustering Regulation Of Immune Response Leukocyte Tethering Or Rolling Positive Regulation Of Lymphocyte Migration
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions RUNX3 Regulates Immune Response and Cell Migration
Drugs		Natalizumab ATL1102 CDP323 R1295 R411 Tinzaparin Vedolizumab
Diseases
GWAS		Celiac disease ( 22057235 20190752) Crohn's disease ( 28067908) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908) Lymphocyte percentage of white cells ( 27863252) Monocyte count ( 23314186 28193307 25096241 29403010 27863252) Monocyte percentage of white cells ( 27863252) Monocyte-lymphocyte ratio ( 28193307) Multiple sclerosis ( 24076602) Neurofibrillary tangles ( 25188341) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Ulcerative colitis ( 28067908) White blood cell count ( 29403010 21738480) White blood cell count (basophil) ( 29403010) White blood cell count (monocyte) ( 28158719) White blood cell types ( 21738478)
Interacting Genes		16 interacting genes: ADAM28 CD81 CD82 EED FN1 ICAM4 ITGB1 ITGB7 LGALS8 LPXN MADCAM1 PRKACA PRKAR1A PXN TGFB1I1 VCAN	3 interacting genes: CD44 ITGA4 ITGB7
Entrez ID		3676	8174
HPRD ID		01894	00035
Ensembl ID		ENSG00000115232	ENSG00000099866
Uniprot IDs		P13612	Q13477
PDB IDs		3V4P 3V4V 4HKC 5C7Z 5FPI	1BQS 1GSM 4HBQ 4HC1 4HCR 4HD9
Enriched GO Terms of Interacting Partners?
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