ITGA3 and HSPD1

Number of citations of the paper that reports this interaction (PubMedID 11888933)
21

Data Source:
HPRD (in vivo)

		ITGA3	HSPD1
Description		integrin subunit alpha 3	heat shock protein family D (Hsp60) member 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Filopodium Membrane Integrin Alpha3-beta1 Complex Receptor Complex Perinuclear Region Of Cytoplasm Excitatory Synapse Extracellular Exosome Invadopodium Membrane Cell Periphery Synaptic Membrane Growth Cone Filopodium	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Early Endosome Peroxisomal Matrix Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Membrane Mitochondrial Crista Coated Vesicle Secretory Granule Protein-containing Complex Zymogen Granule Membrane Raft Lipopolysaccharide Receptor Complex Extracellular Exosome
	Molecular Function	Fibronectin Binding Protease Binding Integrin Binding Protein Binding Collagen Binding Protein Domain Specific Binding Laminin Binding Metal Ion Binding Protein Heterodimerization Activity	Lipopolysaccharide Binding Protease Binding P53 Binding DNA Replication Origin Binding Single-stranded DNA Binding RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding High-density Lipoprotein Particle Binding Isomerase Activity ATPase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Insulin Binding Unfolded Protein Binding Chaperone Binding Modification-dependent Protein Binding
	Biological Process	Neuron Migration Cell-matrix Adhesion Integrin-mediated Signaling Pathway Heart Development Memory Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Wnt Signaling Pathway Extracellular Matrix Organization Lung Development Regulation Of BMP Signaling Pathway Negative Regulation Of Cell Projection Organization Response To Gonadotropin Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Response To Drug Skin Development Mesodermal Cell Differentiation Leukocyte Migration Maternal Process Involved In Female Pregnancy Nephron Development Dendritic Spine Maintenance Renal Filtration Positive Regulation Of Protein Localization To Plasma Membrane	Response To Hypoxia B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Response To Ischemia Regulation Of Transcription By RNA Polymerase II 'de Novo' Protein Folding Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Unfolded Protein Apoptotic Mitochondrial Changes Response To Cold Response To Activity Viral Process Response To Lipopolysaccharide Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Response To ATP Cellular Response To Heat Protein Refolding B Cell Proliferation T Cell Activation B Cell Activation Response To Cocaine Response To Hydrogen Peroxide Positive Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Adhesion Of Symbiont To Host Protein Import Into Mitochondrial Intermembrane Space Isotype Switching To IgG Isotypes Positive Regulation Of Inflammatory Response Protein Stabilization Positive Regulation Of T Cell Activation Chaperone-mediated Protein Complex Assembly Response To Glucocorticoid Protein Maturation Interaction With Symbiont Negative Regulation Of Apoptotic Process In Bone Marrow Cellular Response To Interleukin-7 Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of Interleukin-6 Secretion
Pathways		Basigin interactions Integrin cell surface interactions Integrin cell surface interactions Laminin interactions MET activates PTK2 signaling	Mitochondrial protein import Mitochondrial protein import TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Drugs			Copper
Diseases			Hereditary spastic paraplegia (SPG) Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 25056061 29483656)
Interacting Genes		15 interacting genes: ADAM9 BIN1 CALR CD151 CD82 CD9 FHL2 FN1 HPS5 HSPD1 ITGB1 LGALS8 RABIF TIMP2 TSPAN4	47 interacting genes: ALDH2 APP BAK1 BRCA1 CA2 CASP3 CASP9 CEP70 CLEC7A CLU DHFR ERG FAM107A FHIT H2BC21 HSPE1 ITGA3 ITGB1 KRT31 KRT40 KRTAP10-3 KRTAP10-8 KRTAP5-9 LRRK2 LZTS2 MAPK6 MCPH1 NOS1AP NOTCH2NLA NR3C1 PLCG2 PLG PPP2R1A PPP2R1B PRKACA PRNP PTEN PTPN11 RASA1 RGS20 SAMD3 SUMO4 SUPT6H TLR1 TMCC2 TRIM63 YWHAG
Entrez ID		3675	3329
HPRD ID		05431	00318
Ensembl ID		ENSG00000005884	ENSG00000144381
Uniprot IDs		A0A140VJM0 P26006	A0A024R3X4 P10809
PDB IDs			4PJ1
Enriched GO Terms of Interacting Partners?
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