HSPD1 and PPP2R1A

Number of citations of the paper that reports this interaction (PubMedID 17540176)
91

Data Source:
HPRD (in vivo)

		HSPD1	PPP2R1A
Description		heat shock protein family D (Hsp60) member 1	protein phosphatase 2 scaffold subunit Aalpha
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Early Endosome Peroxisomal Matrix Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Membrane Mitochondrial Crista Coated Vesicle Secretory Granule Protein-containing Complex Zymogen Granule Membrane Raft Lipopolysaccharide Receptor Complex Extracellular Exosome	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Cytoplasm Mitochondrion Cytosol Protein Serine/threonine Phosphatase Complex Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Dendrite Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Lipopolysaccharide Binding Protease Binding P53 Binding DNA Replication Origin Binding Single-stranded DNA Binding RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding High-density Lipoprotein Particle Binding Isomerase Activity ATPase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Insulin Binding Unfolded Protein Binding Chaperone Binding Modification-dependent Protein Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity Protein Heterodimerization Activity Protein Antigen Binding
	Biological Process	Response To Hypoxia B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Response To Ischemia Regulation Of Transcription By RNA Polymerase II 'de Novo' Protein Folding Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Unfolded Protein Apoptotic Mitochondrial Changes Response To Cold Response To Activity Viral Process Response To Lipopolysaccharide Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Response To ATP Cellular Response To Heat Protein Refolding B Cell Proliferation T Cell Activation B Cell Activation Response To Cocaine Response To Hydrogen Peroxide Positive Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Adhesion Of Symbiont To Host Protein Import Into Mitochondrial Intermembrane Space Isotype Switching To IgG Isotypes Positive Regulation Of Inflammatory Response Protein Stabilization Positive Regulation Of T Cell Activation Chaperone-mediated Protein Complex Assembly Response To Glucocorticoid Protein Maturation Interaction With Symbiont Negative Regulation Of Apoptotic Process In Bone Marrow Cellular Response To Interleukin-7 Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of Interleukin-6 Secretion	G2/M Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Inactivation Of MAPK Activity Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Dephosphorylation Ceramide Metabolic Process Apoptotic Process Chromosome Segregation Mitotic Nuclear Envelope Reassembly Female Meiotic Nuclear Division RNA Splicing Response To Organic Substance Regulation Of G2/M Transition Of Mitotic Cell Cycle Second-messenger-mediated Signaling Regulation Of Wnt Signaling Pathway Regulation Of Cell Adhesion Negative Regulation Of Cell Growth Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Cell Differentiation Meiotic Spindle Elongation Mitotic Sister Chromatid Separation Meiotic Sister Chromatid Cohesion, Centromeric Protein-containing Complex Assembly Peptidyl-serine Dephosphorylation Ciliary Basal Body-plasma Membrane Docking Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Mitochondrial protein import Mitochondrial protein import TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Initiation of Nuclear Envelope (NE) Reformation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition AURKA Activation by TPX2 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Copper	2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases		Hereditary spastic paraplegia (SPG) Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 25056061 29483656)
Interacting Genes		47 interacting genes: ALDH2 APP BAK1 BRCA1 CA2 CASP3 CASP9 CEP70 CLEC7A CLU DHFR ERG FAM107A FHIT H2BC21 HSPE1 ITGA3 ITGB1 KRT31 KRT40 KRTAP10-3 KRTAP10-8 KRTAP5-9 LRRK2 LZTS2 MAPK6 MCPH1 NOS1AP NOTCH2NLA NR3C1 PLCG2 PLG PPP2R1A PPP2R1B PRKACA PRNP PTEN PTPN11 RASA1 RGS20 SAMD3 SUMO4 SUPT6H TLR1 TMCC2 TRIM63 YWHAG	45 interacting genes: AIMP2 AKT1 ARIH2 CARD11 CDK1 CSDC2 CSNK2B DAPK1 DELEC1 EEF2 ESR1 GNA12 GRIN1 GRIN2D HSF2 HSPD1 IPO9 MAP3K7 MAPK6 MCM3 PARK7 PLAAT3 PPP2CA PPP2R2A PPP2R3B PPP2R5A PPP4C PPP5C PRDX1 PRDX2 RAB11A RAB18 RAB7A RAP1A RORC SGO1 SGO2 SLC6A2 SMAD2 SMAD3 STRN STRN3 TAB1 TRADD ZFYVE9
Entrez ID		3329	5518
HPRD ID		00318	16184
Ensembl ID		ENSG00000144381	ENSG00000105568
Uniprot IDs		A0A024R3X4 P10809	A8K7B7 P30153
PDB IDs		4PJ1	1B3U 2IE3 2IE4 2NPP 2NYL 2NYM 2PKG 3C5W 3DW8 3K7V 3K7W 4I5L 4I5N 4LAC 5W0W
Enriched GO Terms of Interacting Partners?
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