CXCL10 and CXCR3

Number of citations of the paper that reports this interaction (PubMedID 12782716)
162

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		CXCL10	CXCR3
Description		C-X-C motif chemokine ligand 10	C-X-C motif chemokine receptor 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell External Side Of Plasma Membrane	Cell Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Chemokine Activity Heparin Binding CAMP-dependent Protein Kinase Regulator Activity Chemoattractant Activity CXCR Chemokine Receptor Binding CXCR3 Chemokine Receptor Binding	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding Identical Protein Binding
	Biological Process	Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Muscle Organ Development Blood Circulation Positive Regulation Of Cell Proliferation Response To Cold Response To Gamma Radiation T Cell Chemotaxis Regulation Of T Cell Chemotaxis Response To Auditory Stimulus Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Leukocyte Chemotaxis Response To Vitamin D Cellular Response To Heat Endothelial Cell Activation Regulation Of Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Chemotaxis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotaxis Regulation Of Endothelial Tube Morphogenesis Negative Regulation Of Myoblast Fusion Positive Regulation Of T Cell Migration Regulation Of CAMP-dependent Protein Kinase Activity	Angiogenesis Regulation Of Leukocyte Migration Apoptotic Process Chemotaxis Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration T Cell Chemotaxis Calcium-mediated Signaling Regulation Of Cell Adhesion Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		N-Methylleucine
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) C-X-C motif chemokine 10 levels ( 25147954) Hippocampal volume ( 29274321) Interferon gamma-induced protein 10 levels ( 27989323 31217265) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		5 interacting genes: CCR3 CXCR3 DPP4 IGFBP7 VCAN	6 interacting genes: CXCL10 CXCL11 CXCL13 CXCL9 FATE1 PF4
Entrez ID		3627	2833
HPRD ID		00930	02936
Ensembl ID		ENSG00000169245	ENSG00000186810
Uniprot IDs		P02778	P49682
PDB IDs		1LV9 1O7Y 1O7Z 1O80
Enriched GO Terms of Interacting Partners?
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