CXCL10 and IGFBP7

Number of citations of the paper that reports this interaction (PubMedID 12847218)
12

Data Source:
HPRD (in vivo)

		CXCL10	IGFBP7
Description		C-X-C motif chemokine ligand 10	insulin like growth factor binding protein 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell External Side Of Plasma Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Chemokine Activity Heparin Binding CAMP-dependent Protein Kinase Regulator Activity Chemoattractant Activity CXCR Chemokine Receptor Binding CXCR3 Chemokine Receptor Binding	Extracellular Matrix Structural Constituent Protein Binding Insulin-like Growth Factor Binding
	Biological Process	Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Muscle Organ Development Blood Circulation Positive Regulation Of Cell Proliferation Response To Cold Response To Gamma Radiation T Cell Chemotaxis Regulation Of T Cell Chemotaxis Response To Auditory Stimulus Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Leukocyte Chemotaxis Response To Vitamin D Cellular Response To Heat Endothelial Cell Activation Regulation Of Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Chemotaxis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotaxis Regulation Of Endothelial Tube Morphogenesis Negative Regulation Of Myoblast Fusion Positive Regulation Of T Cell Migration Regulation Of CAMP-dependent Protein Kinase Activity	Regulation Of Cell Growth Cell Adhesion Embryo Implantation Negative Regulation Of Cell Proliferation Response To Heat Response To Retinoic Acid Cellular Response To Hormone Stimulus Post-translational Protein Modification Cellular Protein Metabolic Process Regulation Of Steroid Biosynthetic Process Response To Cortisol
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		N-Methylleucine	Insulin Human Insulin Pork
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) C-X-C motif chemokine 10 levels ( 25147954) Hippocampal volume ( 29274321) Interferon gamma-induced protein 10 levels ( 27989323 31217265) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)	Age-related macular degeneration ( 21909106) Alcohol consumption (max-drinks) ( 29460428) Blood protein levels ( 30072576 29875488 28240269) Brain volume in infants (grey matter) ( 28763065) Congenital heart disease (maternal effect) ( 28468790) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 28869591) Hyperemesis gravidarum ( 29563502) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		5 interacting genes: CCR3 CXCR3 DPP4 IGFBP7 VCAN	11 interacting genes: CCL21 CCL5 CHMP3 CXCL10 IGF1 IGF2 INHBA INS RBBP8 SDC1 VEGFA
Entrez ID		3627	3490
HPRD ID		00930	04183
Ensembl ID		ENSG00000169245	ENSG00000163453
Uniprot IDs		P02778	Q16270
PDB IDs		1LV9 1O7Y 1O7Z 1O80
Enriched GO Terms of Interacting Partners?
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