CXCR2 and CXCL6

Number of citations of the paper that reports this interaction (PubMedID 9692902)
26

Data Source:
HPRD (in vivo)

		CXCR2	CXCL6
Description		C-X-C motif chemokine receptor 2	C-X-C motif chemokine ligand 6
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane Secretory Granule Membrane Mast Cell Granule Mitotic Spindle	Extracellular Region Extracellular Space
	Molecular Function	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding Interleukin-8 Binding	Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding
	Biological Process	Dendritic Cell Chemotaxis Acute Inflammatory Response To Antigenic Stimulus Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Calcium-mediated Signaling Neutrophil Chemotaxis Midbrain Development Receptor Internalization Negative Regulation Of Neutrophil Apoptotic Process Interleukin-8-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Vascular Permeability Neutrophil Degranulation Positive Regulation Of Angiogenesis Cell Chemotaxis Chemokine-mediated Signaling Pathway Metanephric Tubule Morphogenesis Positive Regulation Of Neutrophil Chemotaxis	Leukocyte Homeostasis Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Neutrophil Chemotaxis Leukocyte Chemotaxis Regulation Of Chemokine Production Neutrophil Activation Defense Response To Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Cellular Response To Lipopolysaccharide
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte percentage of white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Smooth-surface caries ( 23470693) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)	Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 30072576 28240269) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil percentage of granulocytes ( 27863252) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neutrophil count ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		21 interacting genes: ADRA1A ARRB1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 ST13	3 interacting genes: CXCR1 CXCR2 MMP9
Entrez ID		3579	6372
HPRD ID		00907	00735
Ensembl ID		ENSG00000180871	ENSG00000124875
Uniprot IDs		P25025 Q53PC4	P80162
PDB IDs		4Q3H 5TYT
Enriched GO Terms of Interacting Partners?
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