CXCR2 and PPBP

Number of citations of the paper that reports this interaction (PubMedID 8702798)
86

Data Source:
HPRD (in vivo)

		CXCR2	PPBP
Description		C-X-C motif chemokine receptor 2	pro-platelet basic protein
Image
GO Annotations	Cellular Component	Cell Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane Secretory Granule Membrane Mast Cell Granule Mitotic Spindle	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Tertiary Granule Lumen
	Molecular Function	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding Interleukin-8 Binding	Glucose Transmembrane Transporter Activity Protein Binding Chemokine Activity Growth Factor Activity CXCR Chemokine Receptor Binding
	Biological Process	Dendritic Cell Chemotaxis Acute Inflammatory Response To Antigenic Stimulus Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Calcium-mediated Signaling Neutrophil Chemotaxis Midbrain Development Receptor Internalization Negative Regulation Of Neutrophil Apoptotic Process Interleukin-8-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Vascular Permeability Neutrophil Degranulation Positive Regulation Of Angiogenesis Cell Chemotaxis Chemokine-mediated Signaling Pathway Metanephric Tubule Morphogenesis Positive Regulation Of Neutrophil Chemotaxis	Platelet Degranulation Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Neutrophil Chemotaxis Leukocyte Chemotaxis Defense Response To Bacterium Neutrophil Degranulation Positive Regulation Of Cell Division Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Glucose Transmembrane Transport
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation	Platelet degranulation Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs			Ethanesulfonic Acid Copper
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte percentage of white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Smooth-surface caries ( 23470693) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)	Metabolite levels ( 22916037)
Interacting Genes		21 interacting genes: ADRA1A ARRB1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 ST13	20 interacting genes: CELF1 CMTM6 COPG1 COPS7A COX17 CTSG CXCR1 CXCR2 DMWD EFNA1 MAPK6 MOB3B NDUFB11 NR4A1 PLEKHJ1 PMAIP1 RAB10 RPS27 SCFD1 STRN4
Entrez ID		3579	5473
HPRD ID		00907	07171
Ensembl ID		ENSG00000180871	ENSG00000163736
Uniprot IDs		P25025 Q53PC4	P02775
PDB IDs		4Q3H 5TYT	1F9P 1NAP 1TVX
Enriched GO Terms of Interacting Partners?
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