PPP2R1A and PPP2CA

Number of citations of the paper that reports this interaction (PubMedID 17540176)
91

Data Source:
HPRD (in vivo, two hybrid)

		PPP2R1A	PPP2CA
Description		protein phosphatase 2 scaffold subunit Aalpha	protein phosphatase 2 catalytic subunit alpha
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Cytoplasm Mitochondrion Cytosol Protein Serine/threonine Phosphatase Complex Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Dendrite Extracellular Exosome Glutamatergic Synapse	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Spindle Pole Nucleus Mitochondrion Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Membrane Raft Synapse Extracellular Exosome
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity Protein Heterodimerization Activity Protein Antigen Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Protein C-terminus Binding Metal Ion Binding Protein Heterodimerization Activity Tau Protein Binding GABA Receptor Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Inactivation Of MAPK Activity Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Dephosphorylation Ceramide Metabolic Process Apoptotic Process Chromosome Segregation Mitotic Nuclear Envelope Reassembly Female Meiotic Nuclear Division RNA Splicing Response To Organic Substance Regulation Of G2/M Transition Of Mitotic Cell Cycle Second-messenger-mediated Signaling Regulation Of Wnt Signaling Pathway Regulation Of Cell Adhesion Negative Regulation Of Cell Growth Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Cell Differentiation Meiotic Spindle Elongation Mitotic Sister Chromatid Separation Meiotic Sister Chromatid Cohesion, Centromeric Protein-containing Complex Assembly Peptidyl-serine Dephosphorylation Ciliary Basal Body-plasma Membrane Docking Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Inactivation Of MAPK Activity Regulation Of Protein Phosphorylation Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Dephosphorylation Ceramide Metabolic Process Apoptotic Process Mitotic Nuclear Envelope Reassembly Mesoderm Development RNA Splicing Response To Organic Substance Response To Lead Ion Negative Regulation Of Epithelial To Mesenchymal Transition Second-messenger-mediated Signaling Regulation Of Wnt Signaling Pathway Regulation Of Cell Adhesion Negative Regulation Of Cell Growth Peptidyl-threonine Dephosphorylation Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cell Differentiation Meiotic Cell Cycle Peptidyl-serine Dephosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Microtubule Binding Positive Regulation Of Microtubule Binding
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Initiation of Nuclear Envelope (NE) Reformation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition AURKA Activation by TPX2 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Initiation of Nuclear Envelope (NE) Reformation CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid	Vitamin E 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS
Interacting Genes		45 interacting genes: AIMP2 AKT1 ARIH2 CARD11 CDK1 CSDC2 CSNK2B DAPK1 DELEC1 EEF2 ESR1 GNA12 GRIN1 GRIN2D HSF2 HSPD1 IPO9 MAP3K7 MAPK6 MCM3 PARK7 PLAAT3 PPP2CA PPP2R2A PPP2R3B PPP2R5A PPP4C PPP5C PRDX1 PRDX2 RAB11A RAB18 RAB7A RAP1A RORC SGO1 SGO2 SLC6A2 SMAD2 SMAD3 STRN STRN3 TAB1 TRADD ZFYVE9	88 interacting genes: ADCY8 AKAP6 AKT1 AKT3 APC AXIN1 BCL2 BEST1 BMPR1B BRAF CAD CAMK1 CARD11 CAV1 CCNG1 CCNG2 CDC42BPB CDK2 CDK6 CDKN2C CEBPA CHEK2 CSNK2B CXCR2 DELEC1 DVL3 EEF2 EIF4EBP1 ETF1 FCAR GABRB3 GAD1 GOLGA2 HTT IGBP1 ISYNA1 JAK2 KISS1R MAPK1 MAPK3 MAPT MID1 MRPS26 MYC MYH9 NME2 NOSIP NXN PACS1 PAK1 PIM1 PPP1CA PPP2R1A PPP2R1B PPP2R2A PPP2R3B PPP2R5B PPP2R5C PPP2R5E PRKAA1 PRKCD PTN PXN PYGM RACGAP1 RBL2 RELA RHO RHOB RORC RPS6KB1 RRAS SET SGK1 SGO1 SGO2 STAT5A STAT5B STRN TIAM1 TLX1 TP53 TRIM28 TRIP13 TSC2 VAC14 VDR XRN1
Entrez ID		5518	5515
HPRD ID		16184	08912
Ensembl ID		ENSG00000105568	ENSG00000113575
Uniprot IDs		A8K7B7 P30153	B3KUN1 P67775
PDB IDs		1B3U 2IE3 2IE4 2NPP 2NYL 2NYM 2PKG 3C5W 3DW8 3K7V 3K7W 4I5L 4I5N 4LAC 5W0W	2IAE 2IE3 2IE4 2NPP 2NYL 2NYM 3C5W 3DW8 3FGA 3K7V 3K7W 3P71 4I5L 4I5N 4IYP 4LAC 5W0W
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?