HSPB2 and FLNC

Number of citations of the paper that reports this interaction (PubMedID 26465331)
5

Data Source:
BioGRID (two hybrid)

		HSPB2	FLNC
Description		heat shock protein family B (small) member 2	filamin C
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Sarcoplasm Z Disc Sarcolemma Costamere
	Molecular Function	Protein Binding Enzyme Activator Activity	Actin Binding Protein Binding Cytoskeletal Protein Binding Ankyrin Binding
	Biological Process	Response To Unfolded Protein Positive Regulation Of Catalytic Activity	Cell Junction Assembly Muscle Fiber Development
Pathways			Cell-extracellular matrix interactions
Drugs
Diseases			Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS			Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)
Interacting Genes		89 interacting genes: A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BEX4 BGN C1QA CAPZA2 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DDX10 DMPK DUSP1 EEF1A1 EIF4A2 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HSPB3 HSPB8 LGALS1 MAPKAPK5 MB MCCC2 MDH1 MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PGM1 PKP2 PPM1K RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 TATDN1 TCAP THEMIS2 THUMPD2 TNNI3 TTN TXNIP UBL5 WDR1 ZNF335	31 interacting genes: ADRA1A ADRA1B ADRA1D CAPN3 FURIN HIPK3 HSPB2 INPPL1 KCND2 KY MAP2K4 MTDH MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2
Entrez ID		3316	2318
HPRD ID		03712	00018
Ensembl ID		ENSG00000170276	ENSG00000128591
Uniprot IDs		A8KAH6 Q16082	Q14315 Q59H94
PDB IDs		6F2R	1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O 4MGX
Enriched GO Terms of Interacting Partners?
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