HMOX2 and KCNMA1

Number of citations of the paper that reports this interaction (PubMedID 15528406)
130

Data Source:
HPRD (in vitro)

		HMOX2	KCNMA1
Description		heme oxygenase 2	potassium calcium-activated channel subfamily M alpha 1
Image
GO Annotations	Cellular Component	Cell Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane	Cell Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Integral Component Of Membrane Apical Plasma Membrane Postsynaptic Membrane
	Molecular Function	Heme Oxygenase (decyclizing) Activity Protein Binding Heme Binding Metal Ion Binding	Actin Binding Voltage-gated Potassium Channel Activity Protein Binding Calcium-activated Potassium Channel Activity Metal Ion Binding Large Conductance Calcium-activated Potassium Channel Activity
	Biological Process	Response To Hypoxia Heme Oxidation Cellular Iron Ion Homeostasis Response To Oxidative Stress Heme Catabolic Process Neutrophil Degranulation Iron Ion Homeostasis	Response To Hypoxia Potassium Ion Transport Response To Osmotic Stress Cellular Potassium Ion Homeostasis Response To Carbon Monoxide Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Volume Response To Calcium Ion Micturition Smooth Muscle Contraction Involved In Micturition Relaxation Of Vascular Smooth Muscle Potassium Ion Transmembrane Transport
Pathways		Heme degradation Neutrophil degranulation Iron uptake and transport	Ca2+ activated K+ channels cGMP effects
Drugs		NADH Stannsoporfin	Chlorzoxazone Bendroflumethiazide Procaine Hydroflumethiazide Hydrochlorothiazide Cromoglicic acid Miconazole Diazoxide Halothane Dequalinium Trimebutine
Diseases
GWAS		Erectile dysfunction ( 30583798)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Blood pressure ( 24954895) Bone mineral density (spine) ( 26911590) Educational attainment ( 25201988) Estimated glomerular filtration rate ( 31152163 31015462) Glucocorticoid-induced osteonecrosis ( 26265699) Heel bone mineral density ( 30598549 28869591) Hypospadias ( 25108383) Initial pursuit acceleration ( 29064472) Intraocular pressure ( 31959993) Lean body mass ( 28552196) Lumbar spine bone mineral density ( 29499414 22504420) Male-pattern baldness ( 28196072) Mortality in heart failure ( 20400778) Myopia ( 27182965) Obesity ( 21708048) Response to ranibizumab in age-related macular degeneration (exudative) ( 30054556) Smoking cessation in chronic obstructive pulmonary disease ( 29631575) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		35 interacting genes: A2M APP ATP5F1B BLOC1S2 CEBPZ CEP126 COPS6 CSNK2A1 EEF1G EIF3C GIT1 GPRASP1 HAP1 IMMT INPP5K ITFG1 JADE1 KCNMA1 LMNA LRIF1 MARK3 MED31 MTNR1A NDUFS2 NKRF NR3C1 PLXNB2 RBBP4 SETDB1 SHC1 SKA2 SNX5 SNX7 ZFP28 ZNF746	6 interacting genes: CACNA1H GGT1 HMOX2 KCNMB1 MAP1A PTK2
Entrez ID		3163	3778
HPRD ID		00783	15967
Ensembl ID		ENSG00000103415	ENSG00000156113
Uniprot IDs		A0A087WT44 B3KSE0 P30519	A0A087WZL8 A0A1W2PP94 A0A1W2PPY5 A0A1W2PQK5 A0A1W2PQU4 A0A1W2PR56 A0A1W2PR62 A0A1W2PRN5 A0A1W2PSD3 B7ZMF5 D5MRH1 Q12791 Q59FH2 Q5SVJ7 S4R453
PDB IDs		2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA	2K44 3MT5 3NAF
Enriched GO Terms of Interacting Partners?
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