HMOX2 and SKA2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		HMOX2	SKA2
Description		heme oxygenase 2	spindle and kinetochore associated complex subunit 2
Image
GO Annotations	Cellular Component	Cell Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane	Condensed Chromosome Outer Kinetochore Cytosol Spindle Microtubule
	Molecular Function	Heme Oxygenase (decyclizing) Activity Protein Binding Heme Binding Metal Ion Binding	Protein Binding Microtubule Binding
	Biological Process	Response To Hypoxia Heme Oxidation Cellular Iron Ion Homeostasis Response To Oxidative Stress Heme Catabolic Process Neutrophil Degranulation Iron Ion Homeostasis	Mitotic Cell Cycle Chromosome Segregation Regulation Of Microtubule Polymerization Or Depolymerization Cell Division
Pathways		Heme degradation Neutrophil degranulation Iron uptake and transport	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		NADH Stannsoporfin
Diseases
GWAS		Erectile dysfunction ( 30583798)	Cognitive function ( 25644384) Testicular germ cell tumor ( 23666239)
Interacting Genes		35 interacting genes: A2M APP ATP5F1B BLOC1S2 CEBPZ CEP126 COPS6 CSNK2A1 EEF1G EIF3C GIT1 GPRASP1 HAP1 IMMT INPP5K ITFG1 JADE1 KCNMA1 LMNA LRIF1 MARK3 MED31 MTNR1A NDUFS2 NKRF NR3C1 PLXNB2 RBBP4 SETDB1 SHC1 SKA2 SNX5 SNX7 ZFP28 ZNF746	4 interacting genes: HMOX2 PRKD3 SKA1 SPC24
Entrez ID		3163	348235
HPRD ID		00783	13306
Ensembl ID		ENSG00000103415	ENSG00000182628
Uniprot IDs		A0A087WT44 B3KSE0 P30519	J3KSP0 Q8WVK7
PDB IDs		2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA	4AJ5
Enriched GO Terms of Interacting Partners?
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