ZNRD1 and DUSP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ZNRD1	DUSP1
Description		zinc ribbon domain containing 1	dual specificity phosphatase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm RNA Polymerase I Complex	Nucleus Cytoplasm
	Molecular Function	Nucleic Acid Binding DNA-directed 5'-3' RNA Polymerase Activity Zinc Ion Binding	Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Growth Factor Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription MRNA Cleavage Positive Regulation Of Gene Expression, Epigenetic	Inactivation Of MAPK Activity Endoderm Formation Negative Regulation Of Cell Adhesion Negative Regulation Of Cell Proliferation Response To Light Stimulus Response To Estradiol Response To Retinoic Acid Cellular Response To Hormone Stimulus Response To Testosterone Peptidyl-tyrosine Dephosphorylation Intracellular Signal Transduction Peptidyl-threonine Dephosphorylation Response To Hydrogen Peroxide Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Response To Glucocorticoid Negative Regulation Of Meiotic Cell Cycle Response To CAMP Response To Calcium Ion Peptidyl-serine Dephosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Mitotic Cell Cycle Arrest Negative Regulation Of Monocyte Chemotaxis Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of P38MAPK Cascade Cellular Response To Chemokine Negative Regulation Of DNA Biosynthetic Process
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway
Drugs
Diseases
GWAS		AIDS progression ( 19115949) Anger ( 24489884) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) HIV-1 control ( 20041166) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Squamous cell lung carcinoma ( 28604730)	C-reactive protein levels ( 30388399) Diastolic blood pressure ( 30224653) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Offspring birth weight ( 31043758) Optic cup area ( 28073927) Ulcerative colitis ( 26192919) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		17 interacting genes: APOA1 ATXN2 CIC DUSP1 FHL3 GFI1B GPR20 HAX1 IL15 IVNS1ABP MAPK8IP2 NONO SACS SERPINA3 TNS2 UBE2I ZNF593	14 interacting genes: AATK CKS1B HSPA4 HSPB2 MAPK1 MAPK12 MAPK14 MAPK3 MAPK8 MAPT ROR2 SKP2 UBB ZNRD1
Entrez ID		30834	1843
HPRD ID		09601	02835
Ensembl ID		ENSG00000066379	ENSG00000120129
Uniprot IDs		Q2L6J2 Q9P1U0	B4DU40 P28562
PDB IDs			6APX 6D65 6D66 6D67
Enriched GO Terms of Interacting Partners?
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