DUSP1 and AATK

Number of citations of the paper that reports this interaction (PubMedID 28065597)
26

Data Source:
BioGRID (two hybrid)

		DUSP1	AATK
Description		dual specificity phosphatase 1	apoptosis associated tyrosine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cellular_component Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Growth Factor Binding Mitogen-activated Protein Kinase Binding	Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Inactivation Of MAPK Activity Endoderm Formation Negative Regulation Of Cell Adhesion Negative Regulation Of Cell Proliferation Response To Light Stimulus Response To Estradiol Response To Retinoic Acid Cellular Response To Hormone Stimulus Response To Testosterone Peptidyl-tyrosine Dephosphorylation Intracellular Signal Transduction Peptidyl-threonine Dephosphorylation Response To Hydrogen Peroxide Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Response To Glucocorticoid Negative Regulation Of Meiotic Cell Cycle Response To CAMP Response To Calcium Ion Peptidyl-serine Dephosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Mitotic Cell Cycle Arrest Negative Regulation Of Monocyte Chemotaxis Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of P38MAPK Cascade Cellular Response To Chemokine Negative Regulation Of DNA Biosynthetic Process	Biological_process Peptidyl-tyrosine Phosphorylation
Pathways		RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway
Drugs
Diseases
GWAS		C-reactive protein levels ( 30388399) Diastolic blood pressure ( 30224653) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Offspring birth weight ( 31043758) Optic cup area ( 28073927) Ulcerative colitis ( 26192919) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Neuroticism ( 29255261) Obesity-related traits ( 23251661) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		14 interacting genes: AATK CKS1B HSPA4 HSPB2 MAPK1 MAPK12 MAPK14 MAPK3 MAPK8 MAPT ROR2 SKP2 UBB ZNRD1	40 interacting genes: CDC14A CDC25B CDK5 DUPD1 DUSP1 DUSP14 DUSP5 DUSP6 DUSP9 EYA2 EYA4 ILKAP MTMR10 MTMR6 MTMR8 MTMR9 PPM1A PPM1B PPM1F PPM1K PPM1M PPP1CA PPP1CB PPP1CC PPP3CA PPP3CB PTEN PTPDC1 PTPN11 PTPN12 PTPN18 PTPN20 PTPN6 PTPN7 PTPRR SBF1 STK39 STYX TAB1 TPTE2
Entrez ID		1843	9625
HPRD ID		02835	05591
Ensembl ID		ENSG00000120129	ENSG00000181409
Uniprot IDs		B4DU40 P28562	H7C175 Q6ZMQ8
PDB IDs		6APX 6D65 6D66 6D67
Enriched GO Terms of Interacting Partners?
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