CNOT7 and TOB2

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		CNOT7	TOB2
Description		CCR4-NOT transcription complex subunit 7	transducer of ERBB2, 2
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane Nuclear Body Nuclear Speck CCR4-NOT Complex CCR4-NOT Core Complex Host Cell PML Body	Nucleus Cytoplasm Cytosol
	Molecular Function	3'-5'-exoribonuclease Activity Transcription Corepressor Activity RNA Binding Exoribonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Transcription Factor Binding Metal Ion Binding	Transcription Corepressor Activity Protein Binding Vitamin D Receptor Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Translation Gene Silencing By RNA Cytoplasmic MRNA Processing Body Assembly Gene Silencing By MiRNA Regulation Of Tyrosine Phosphorylation Of STAT Protein Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of Viral Genome Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Female Gamete Generation Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Ossification Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310) Autism spectrum disorder or schizophrenia ( 28540026) Neuroticism ( 29255261) Vitiligo ( 22561518)
Interacting Genes		29 interacting genes: APP BTG1 BTG2 BTG3 CDK1 CDK2 CDK4 CDK6 CNOT6 FBXO7 FHL3 FOXC2 HOXD4 IKBKG LSM3 MRFAP1L1 NMI PABPC1 PIAS1 PSMC1 PSMC2 RAD54L2 SCARA3 SH3GLB2 TEX11 TNRC6A TOB1 TOB2 TSG101	5 interacting genes: BHLHE40 CEP76 CNOT7 CNOT8 RPS6KA1
Entrez ID		29883	10766
HPRD ID		05370	09583
Ensembl ID		ENSG00000198791	ENSG00000183864
Uniprot IDs		Q96IQ6 Q9UIV1	Q14106
PDB IDs		2D5R 4GMJ
Enriched GO Terms of Interacting Partners?
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