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CNOT7 and CDK4
Number of citations of the paper that reports this interaction (PubMedID
10602502
)
38
Data Source:
HPRD
(in vivo)
CNOT7
CDK4
Description
CCR4-NOT transcription complex subunit 7
cyclin dependent kinase 4
Image
GO Annotations
Cellular Component
P-body
Nucleus
Cytoplasm
Cytosol
Membrane
Nuclear Body
Nuclear Speck
CCR4-NOT Complex
CCR4-NOT Core Complex
Host Cell PML Body
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Factor Complex
Nucleolus
Cytosol
Bicellular Tight Junction
Nuclear Membrane
Perinuclear Region Of Cytoplasm
Cyclin D2-CDK4 Complex
Molecular Function
3'-5'-exoribonuclease Activity
Transcription Corepressor Activity
RNA Binding
Exoribonuclease Activity
Poly(A)-specific Ribonuclease Activity
Protein Binding
Transcription Factor Binding
Metal Ion Binding
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Cyclin Binding
Protein-containing Complex Binding
Biological Process
Nuclear-transcribed MRNA Poly(A) Tail Shortening
Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Negative Regulation Of Gene Expression
Negative Regulation Of Translation
Gene Silencing By RNA
Cytoplasmic MRNA Processing Body Assembly
Gene Silencing By MiRNA
Regulation Of Tyrosine Phosphorylation Of STAT Protein
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Positive Regulation Of Viral Genome Replication
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Defense Response To Virus
Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Positive Regulation Of MRNA Catabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Lens Development In Camera-type Eye
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Signal Transduction
Circadian Rhythm
Positive Regulation Of Cell Proliferation
Response To Toxic Substance
Response To Lead Ion
Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Animal Organ Regeneration
Cellular Response To Insulin Stimulus
Response To Testosterone
Regulation Of Multicellular Organism Growth
Response To Drug
Positive Regulation Of Apoptotic Process
Positive Regulation Of Translation
Positive Regulation Of Cell Cycle
Positive Regulation Of Cell Size
Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Lipid Biosynthetic Process
Positive Regulation Of Fibroblast Proliferation
Regulation Of Lipid Catabolic Process
Cell Division
Response To Hyperoxia
Adipose Tissue Development
Negative Regulation Of Cell Cycle Arrest
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-4
Cellular Response To Phorbol 13-acetate 12-myristate
Cellular Response To Ionomycin
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Deadenylation of mRNA
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
SCF(Skp2)-mediated degradation of p27/p21
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
RMTs methylate histone arginines
Transcriptional regulation of white adipocyte differentiation
Cyclin D associated events in G1
Ubiquitin-dependent degradation of Cyclin D
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates Cell Cycle
Transcriptional regulation by RUNX2
Meiotic recombination
Transcriptional regulation of granulopoiesis
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Drugs
Purvalanol
Alvocidib
Palbociclib
Ribociclib
Abemaciclib
Diseases
Glioma
Malignant melanoma
Cervical cancer
GWAS
Celiac disease or Rheumatoid arthritis (
21383967
)
Rheumatoid arthritis (
30423114
24390342
)
Interacting Genes
29 interacting genes:
APP
BTG1
BTG2
BTG3
CDK1
CDK2
CDK4
CDK6
CNOT6
FBXO7
FHL3
FOXC2
HOXD4
IKBKG
LSM3
MRFAP1L1
NMI
PABPC1
PIAS1
PSMC1
PSMC2
RAD54L2
SCARA3
SH3GLB2
TEX11
TNRC6A
TOB1
TOB2
TSG101
131 interacting genes:
AKT1
ANKRD12
ANXA7
APLP1
APP
ARAF
ARID4A
ARNT
ATP5F1B
BAG6
BCL11A
BECN1
BIRC5
BMPR1B
BRCA1
CAMK1
CAPNS1
CCND1
CCND2
CCND3
CCNE1
CD44
CDC37
CDC45
CDC6
CDC7
CDK6
CDKN1A
CDKN1B
CDKN1C
CDKN2A
CDKN2B
CDKN2C
CDKN2D
CEBPA
CIB1
CNOT7
CNTN2
DAZAP2
DDAH2
DUSP9
EIF4EBP2
EPHA2
ERBB2
FGFR4
FOXM1
FZR1
GLIS2
GRM1
H1-0
H1-1
H1-3
HGF
HIF1A
HMGXB3
HOOK1
HSP90AA1
IFI27
IGF1R
IL15RA
KDELR2
LATS2
LNX2
LUC7L2
MAP2K3
MAP2K5
MAP3K5
MAPK14
MAPRE2
MARCKS
MCM2
MDM4
MET
MYC
MYOD1
MZF1
NCOA2
NF2
NOL12
ORC3
OTX2
PDGFRA
PGD
PIAS1
PKM
POLD1
PPP2R1B
PRKAR1A
PSMD10
PTMA
QARS1
RAF1
RASSF1
RB1
RBL1
RBL2
RFC1
RFC4
RPL34
SENP3
SERTAD1
SETDB1
SHOX2
SKP1
SLBP
SMAD2
SMAD3
SNCA
SPOP
STK11
STUB1
TEAD2
TERT
TGFBR1
TK1
TP53
TRMT2A
TSC1
TSPYL2
UBE3A
UBTF
UHRF2
USP17L2
VTA1
WDR33
YBX3
ZBTB16
ZNF101
ZNF219
ZNF335
ZNF655
Entrez ID
29883
1019
HPRD ID
05370
00447
Ensembl ID
ENSG00000198791
ENSG00000135446
Uniprot IDs
Q96IQ6
Q9UIV1
A0A024RBB6
P11802
PDB IDs
2D5R
4GMJ
1LD2
2W96
2W99
2W9F
2W9Z
3G33
5FWK
5FWL
5FWM
5FWP
Enriched GO Terms of Interacting Partners
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