TOB2 and BHLHE40

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TOB2	BHLHE40
Description		transducer of ERBB2, 2	basic helix-loop-helix family member e40
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nuclear Chromatin Nucleus Cytoplasm Nuclear Body
	Molecular Function	Transcription Corepressor Activity Protein Binding Vitamin D Receptor Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	Female Gamete Generation Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Ossification Negative Regulation Of Nucleic Acid-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Circadian Rhythm Anterior/posterior Pattern Specification Cell Differentiation Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis
Pathways			BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310) Autism spectrum disorder or schizophrenia ( 28540026) Neuroticism ( 29255261) Vitiligo ( 22561518)	Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Psoriasis vulgaris ( 26626624) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		5 interacting genes: BHLHE40 CEP76 CNOT7 CNOT8 RPS6KA1	51 interacting genes: AAMP AANAT APH1A ARNTL BHLHE41 BRD7 CALML3 CCNK CDPF1 CHD3 COX5B DAB1 EHHADH ENO1 FBLN1 GMCL2 HDAC1 HIVEP1 HNRNPLL KRTAP23-1 LARP4 MAGED1 MYOD1 NAA50 NOC4L NUMBL PDE6G PLEKHB2 PRKAA1 RBFOX1 RBM23 RBPMS RHOBTB3 RHOJ SETDB1 SIN3A SMARCB1 SMYD1 SOX15 STAT3 STK19 TCF3 TLE5 TOB2 TOLLIP TTC23 TXNL4B UBE2I VAC14 VIM ZHX1
Entrez ID		10766	8553
HPRD ID		09583	16050
Ensembl ID		ENSG00000183864	ENSG00000134107
Uniprot IDs		Q14106	O14503 Q6IB83
PDB IDs
Enriched GO Terms of Interacting Partners?
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