FYB1 and LCP2

Number of citations of the paper that reports this interaction (PubMedID 9207119)
77

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		FYB1	LCP2
Description		FYN binding protein 1	lymphocyte cytosolic protein 2
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GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Actin Cytoskeleton Cell Junction Protein-containing Complex	Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft
	Molecular Function	Signaling Receptor Binding Protein Binding Lipid Binding Protein-containing Complex Binding	Protein Binding
	Biological Process	Immune Response Integrin-mediated Signaling Pathway Biological_process T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Mast Cell Activation Positive Regulation Of Protein Kinase Activity Cytokine Secretion T Cell Receptor Signaling Pathway
Pathways		Generation of second messenger molecules Generation of second messenger molecules Signal regulatory protein family interactions	GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS			Acne (severe) ( 24927181) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		15 interacting genes: BCAR1 CBL CBLB ENAH EVL FASLG FYN LCP2 NCK2 SH2D1A SKAP1 SKAP2 SRC VASP WAS	43 interacting genes: APP BLNK CBL CD22 CLNK EGFR FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LARP1 LAT LCK LMNA LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70
Entrez ID		2533	3937
HPRD ID		04107	03362
Ensembl ID		ENSG00000082074	ENSG00000043462
Uniprot IDs		O15117	Q13094
PDB IDs		1RI9 2GTJ 2GTO	1H3H 1YWO 2EAP 2ROR
Enriched GO Terms of Interacting Partners?
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