FYB1 and SKAP2

Number of citations of the paper that reports this interaction (PubMedID 9671755)
47

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		FYB1	SKAP2
Description		FYN binding protein 1	src kinase associated phosphoprotein 2
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GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Actin Cytoskeleton Cell Junction Protein-containing Complex	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Lipid Binding Protein-containing Complex Binding	SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Immune Response Integrin-mediated Signaling Pathway Biological_process T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane	Signal Transduction Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction B Cell Activation Protein-containing Complex Assembly
Pathways		Generation of second messenger molecules Generation of second messenger molecules Signal regulatory protein family interactions	Signal regulatory protein family interactions
Drugs
Diseases
GWAS			Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic venous disease ( 28374850) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Peak expiratory flow ( 30804560) Small cell lung carcinoma ( 28604730) Systemic lupus erythematosus ( 28714469)
Interacting Genes		15 interacting genes: BCAR1 CBL CBLB ENAH EVL FASLG FYN LCP2 NCK2 SH2D1A SKAP1 SKAP2 SRC VASP WAS	19 interacting genes: APP BLK FAM102A FASLG FGR FRK FYB1 FYN HCK KHDRBS1 LCK LYN NCK2 PRAM1 PTK2B SRC SRMS TGFBR1 YES1
Entrez ID		2533	8935
HPRD ID		04107	05558
Ensembl ID		ENSG00000082074	ENSG00000005020
Uniprot IDs		O15117	B7Z5R3 O75563
PDB IDs		1RI9 2GTJ 2GTO	3OMH
Enriched GO Terms of Interacting Partners?
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