LCP2 and ZAP70

Number of citations of the paper that reports this interaction (PubMedID 8702662)
85

Data Source:
HPRD (in vitro, in vivo)

		LCP2	ZAP70
Description		lymphocyte cytosolic protein 2	zeta chain of T cell receptor associated protein kinase 70
Image
GO Annotations	Cellular Component	Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction T Cell Receptor Complex Membrane Raft
	Molecular Function	Protein Binding	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Mast Cell Activation Positive Regulation Of Protein Kinase Activity Cytokine Secretion T Cell Receptor Signaling Pathway	Adaptive Immune Response Protein Phosphorylation Immune Response Peptidyl-tyrosine Phosphorylation T Cell Differentiation Intracellular Signal Transduction T Cell Activation B Cell Activation Beta Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Protein Autophosphorylation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway T Cell Aggregation T Cell Migration
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules
Drugs			Staurosporine
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Acne (severe) ( 24927181) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)	Bipolar disorder ( 31043756) Cardiac Troponin-T levels ( 31014085) Diastolic blood pressure ( 30224653)
Interacting Genes		43 interacting genes: APP BLNK CBL CD22 CLNK EGFR FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LARP1 LAT LCK LMNA LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70	62 interacting genes: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DAPK1 DBNL DEF6 DUSP3 EGFR ERBB3 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 LAT LAX1 LCK LCP2 LRRK2 MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 RNF41 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP USP2 VAV1 WIPF1
Entrez ID		3937	7535
HPRD ID		03362	01495
Ensembl ID		ENSG00000043462	ENSG00000115085
Uniprot IDs		Q13094	P43403
PDB IDs		1H3H 1YWO 2EAP 2ROR	1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R 4XZ0 4XZ1 5O76
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?