MYCBP2 and PTPN12

Number of citations of the paper that reports this interaction (PubMedID 15231748)
85

Data Source:
HPRD (two hybrid)

		MYCBP2	PTPN12
Description		MYC binding protein 2	protein tyrosine phosphatase non-receptor type 12
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton Membrane Axon Intracellular Membrane-bounded Organelle	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Cell Projection
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Ran GTPase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding
	Biological Process	Protein Ubiquitination Branchiomotor Neuron Axon Guidance Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of Protein Ubiquitination Regulation Of Protein Localization Circadian Regulation Of Gene Expression Negative Regulation Of Protein Catabolic Process Neuromuscular Process Regulation Of Cytoskeleton Organization Regulation Of Axon Guidance	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tissue Regeneration Cellular Response To Cytokine Stimulus Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways			SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2
Drugs
Diseases
GWAS		Chronotype ( 30696823) Iris heterochromicity ( 30895295) Morning person ( 30696823) Preeclampsia ( 23551011) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Estimated glomerular filtration rate ( 31015462)
Interacting Genes		20 interacting genes: ATP13A2 ATP1B3 CALM1 CDC14B COMMD6 DACH1 EDNRB FBXL3 FBXO45 MAST3 MYC NMNAT2 PTPN12 SCEL SRPK2 UBE2D2 UBE2D3 UBE2L3 YWHAG YWHAQ	48 interacting genes: AATK ABL1 APP BAG6 BCAR1 CGA CSH1 CSH2 CSK EFS EGFR EIF4H ERBB3 ERBB4 FGFR2 FGFR4 FLT3 GRB2 IFT20 IGF1R INSR JAK2 KDR LMTK2 LPXN MYCBP2 NEDD9 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PTK7 PXN RBM19 ROR2 SHC1 SMAD5 SORBS2 STX16 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2
Entrez ID		23077	5782
HPRD ID		10104	02513
Ensembl ID		ENSG00000005810	ENSG00000127947
Uniprot IDs		O75592	B4E105 Q05209
PDB IDs		5O6C	5HDE 5J8R 5O2P
Enriched GO Terms of Interacting Partners?
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