PTPN12 and ERBB3

Number of citations of the paper that reports this interaction (PubMedID 28065597)
26

Data Source:
BioGRID (two hybrid)

		PTPN12	ERBB3
Description		protein tyrosine phosphatase non-receptor type 12	erb-b2 receptor tyrosine kinase 3
Image
GO Annotations	Cellular Component	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Cell Projection	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane ERBB3:ERBB2 Complex Receptor Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Tyrosine Kinase Activator Activity Ubiquitin Protein Ligase Binding Neuregulin Receptor Activity Neuregulin Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tissue Regeneration Cellular Response To Cytokine Stimulus Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	MAPK Cascade Endocardial Cushion Development Negative Regulation Of Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Peripheral Nervous System Development Heart Development Positive Regulation Of Cell Proliferation Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Schwann Cell Differentiation Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cranial Nerve Development Positive Regulation Of Kinase Activity ERBB2 Signaling Pathway Wound Healing Regulation Of Cell Proliferation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Secretion Neuron Apoptotic Process Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Calcineurin-NFAT Signaling Cascade Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Motility
Pathways		SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2
Drugs
Diseases			Lethal congenital contractural syndrome (LCCS) Type I diabetes mellitus
GWAS		Estimated glomerular filtration rate ( 31015462)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Alopecia areata ( 25608926) Anorexia nervosa ( 28494655) Asthma ( 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Cognitive function ( 25644384) Household income (MTAG) ( 31844048) Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Polycystic ovary syndrome ( 26416764) Smoking initiation ( 30617275) Type 1 diabetes ( 21829393 19430480 18198356 17554260 17554300 18978792) Vitiligo ( 22951725)
Interacting Genes		48 interacting genes: AATK ABL1 APP BAG6 BCAR1 CGA CSH1 CSH2 CSK EFS EGFR EIF4H ERBB3 ERBB4 FGFR2 FGFR4 FLT3 GRB2 IFT20 IGF1R INSR JAK2 KDR LMTK2 LPXN MYCBP2 NEDD9 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PTK7 PXN RBM19 ROR2 SHC1 SMAD5 SORBS2 STX16 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2	100 interacting genes: ABL1 ABL2 AGTR2 BCAR3 CD82 CDC25C CDK5 CHN2 CRK CRKL CSPG5 DAB1 DAPP1 DUPD1 DUSP14 DUSP18 DUSP19 DUSP21 EGF EGFR EGR1 ERBB2 ERBB4 EYA4 FER FGFR1 FLNA FLYWCH1 GRB2 GRB7 HCK HDAC6 IL6ST ILKAP ITK JAK2 JAK3 MTMR1 MTMR10 MTMR2 MTMR6 MTMR8 MTMR9 MUC1 MUC4 NCK1 NCK2 NEDD4 NRG1 NRG2 ODF2L PA2G4 PIK3R1 PIK3R2 PIK3R3 PLCG1 PPM1A PPM1B PPM1F PPM1K PPM1M PRKACA PTEN PTGES3 PTK2 PTK2B PTK6 PTPDC1 PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRH PTPRR RASA1 RASA4 RGS4 RIN1 RNF41 RPN1 SH2B3 SH2D1A SHC1 SHC3 SOS1 SRC SRPK2 STYX SYK TNS2 TNS3 TNS4 TPTE TXK VAV1 VAV2 VAV3 ZAP70 ZNF207
Entrez ID		5782	2065
HPRD ID		02513	01820
Ensembl ID		ENSG00000127947	ENSG00000065361
Uniprot IDs		B4E105 Q05209	P21860
PDB IDs		5HDE 5J8R 5O2P	1M6B 2L9U 3KEX 3LMG 3P11 4LEO 4P59 4RIW 4RIX 4RIY 5CUS 5O4O 5O7P 6OP9
Enriched GO Terms of Interacting Partners?
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