SMG1 and CDH5

Number of citations of the paper that reports this interaction (PubMedID 10428027)
339

Data Source:
HPRD (in vivo)

		SMG1	CDH5
Description		SMG1 nonsense mediated mRNA decay associated PI3K related kinase	cadherin 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cell Nucleoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Catenin Complex Cell Junction Nuclear Membrane
	Molecular Function	RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Telomeric DNA Binding Metal Ion Binding	Signaling Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Protein Phosphatase Binding Vascular Endothelial Growth Factor Receptor 2 Binding Ion Channel Binding Cadherin Binding Fibrinogen Binding BMP Receptor Binding Protein Tyrosine Kinase Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay DNA Repair MRNA Export From Nucleus Peptidyl-serine Phosphorylation Regulation Of Telomere Maintenance Protein Autophosphorylation Phosphatidylinositol Phosphorylation Regulation Of Response To DNA Damage Stimulus	Cell Morphogenesis Regulation Of Protein Phosphorylation Blood Vessel Maturation Cellular Calcium Ion Homeostasis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Transforming Growth Factor Beta Receptor Signaling Pathway Multicellular Organism Development Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Microtubule Polymerization Positive Regulation Of Protein Complex Assembly Adherens Junction Organization Positive Regulation Of Protein Dephosphorylation Regulation Of Vascular Permeability Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Bicellular Tight Junction Assembly Cell-cell Adhesion Protein Localization To Bicellular Tight Junction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Establishment Of Cell Polarity
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Adherens junctions interactions VEGFR2 mediated vascular permeability
Drugs			Lenalidomide FX06
Diseases
GWAS		Health literacy ( 31250787) Heel bone mineral density ( 30598549)	Iron status biomarkers (ferritin levels) ( 28334935) Lung function (FEV1/FVC) ( 30061609) Molar-incisor hypomineralization ( 23918034)
Interacting Genes		9 interacting genes: CDH5 ELOB PRKCI SMAD9 SMG5 SMG8 UPF1 UPF2 UPF3A	21 interacting genes: CSK CTNNA1 CTNNB1 CTNND1 DSP EGFR EPHA2 F2RL2 FGA JUP KDR P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB SHC1 SMG1 SRC VIM
Entrez ID		23049	1003
HPRD ID		06123	03075
Ensembl ID		ENSG00000157106	ENSG00000179776
Uniprot IDs		Q96Q15	P33151 Q59EA3
PDB IDs
Enriched GO Terms of Interacting Partners?
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