CDH5 and SMG1

Number of citations of the paper that reports this interaction (PubMedID 10428027)
339

Data Source:
HPRD (in vivo)

		CDH5	SMG1
Description		cadherin 5	SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Nucleoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Catenin Complex Cell Junction Nuclear Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Signaling Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Protein Phosphatase Binding Vascular Endothelial Growth Factor Receptor 2 Binding Ion Channel Binding Cadherin Binding Fibrinogen Binding BMP Receptor Binding Protein Tyrosine Kinase Binding	RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Telomeric DNA Binding Metal Ion Binding
	Biological Process	Cell Morphogenesis Regulation Of Protein Phosphorylation Blood Vessel Maturation Cellular Calcium Ion Homeostasis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Transforming Growth Factor Beta Receptor Signaling Pathway Multicellular Organism Development Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Microtubule Polymerization Positive Regulation Of Protein Complex Assembly Adherens Junction Organization Positive Regulation Of Protein Dephosphorylation Regulation Of Vascular Permeability Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Bicellular Tight Junction Assembly Cell-cell Adhesion Protein Localization To Bicellular Tight Junction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Establishment Of Cell Polarity	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay DNA Repair MRNA Export From Nucleus Peptidyl-serine Phosphorylation Regulation Of Telomere Maintenance Protein Autophosphorylation Phosphatidylinositol Phosphorylation Regulation Of Response To DNA Damage Stimulus
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Lenalidomide FX06
Diseases
GWAS		Iron status biomarkers (ferritin levels) ( 28334935) Lung function (FEV1/FVC) ( 30061609) Molar-incisor hypomineralization ( 23918034)	Health literacy ( 31250787) Heel bone mineral density ( 30598549)
Interacting Genes		21 interacting genes: CSK CTNNA1 CTNNB1 CTNND1 DSP EGFR EPHA2 F2RL2 FGA JUP KDR P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB SHC1 SMG1 SRC VIM	9 interacting genes: CDH5 ELOB PRKCI SMAD9 SMG5 SMG8 UPF1 UPF2 UPF3A
Entrez ID		1003	23049
HPRD ID		03075	06123
Ensembl ID		ENSG00000179776	ENSG00000157106
Uniprot IDs		P33151 Q59EA3	Q96Q15
PDB IDs
Enriched GO Terms of Interacting Partners?
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