RPH3A and NRXN1

Number of citations of the paper that reports this interaction (PubMedID 8901523)
6

Data Source:
HPRD (in vitro)

		RPH3A	NRXN1
Description		rabphilin 3A	neurexin 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Synaptic Vesicle Extrinsic Component Of Membrane Cell Junction Secretory Granule Synaptic Vesicle Membrane Protein-containing Complex Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane	Nucleolus Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Cell Junction Nuclear Membrane Vesicle Protein-containing Complex Presynaptic Membrane Cell Projection Neuronal Cell Body Schaffer Collateral - CA1 Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Active Zone Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Zinc Ion Binding Selenium Binding Rab GTPase Binding Phosphate Ion Binding Protein-containing Complex Binding Inositol 1,4,5 Trisphosphate Binding Phosphatidylinositol Phosphate Binding	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Acetylcholine Receptor Binding Signaling Receptor Activity Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Intracellular Protein Transport Spontaneous Neurotransmitter Secretion	Neuron Cell-cell Adhesion Chemical Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Adult Behavior Social Behavior Vocal Learning Neuromuscular Process Controlling Balance Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Vocalization Behavior Positive Regulation Of Synapse Maturation Postsynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Regulation Of Synaptic Vesicle Cycle Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Endocannabinoid Synaptic Membrane Adhesion Regulation Of Presynapse Assembly Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Grooming Behavior
Pathways			Neurexins and neuroligins Neurexins and neuroligins Non-integrin membrane-ECM interactions Neurexins and neuroligins Neurexins and neuroligins
Drugs			Calcium Citrate Calcium Phosphate
Diseases			Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
GWAS		Alcohol consumption (max-drinks) ( 29460428) Body mass index ( 26426971) Chloride levels ( 29403010) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Low density lipoprotein cholesterol levels ( 29403010) Low HDL-cholesterol levels ( 31006500) Platelet count ( 22139419) Urate levels ( 31578528)	Body mass index ( 28892062) Chromosomal aberration frequency (chromatid type) ( 31586183) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Educational attainment ( 25201988) General risk tolerance (MTAG) ( 30643258) Isovolumetric relaxation time ( 28394258) Lateral ventricle temporal horn volume ( 31530798) Longevity ( 20834067) Lung cancer in ever smokers ( 28604730) Metabolite levels (HVA/MHPG ratio) ( 23319000) Morning person ( 30696823) Personality dimensions ( 20691247) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive astigmatism ( 25367360) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Severe gingival inflammation ( 28459102) Systolic blood pressure ( 30224653 30578418) Temperament ( 22832960) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Word spelling ( 30741946)
Interacting Genes		10 interacting genes: ADD2 CASK GCH1 NRXN1 RAB15 RAB27A RAB3A RAB3B RAB8A YWHAH	29 interacting genes: AFDN APBA1 APBA2 ATP13A2 CASK MACF1 MYO16 NLGN1 NLGN2 NLGN3 NXPH1 NXPH2 NXPH3 PDZD2 RPH3A RTN4 SDCBP2 SIPA1L1 SYT1 SYT13 SYT2 SYT4 SYT5 SYT6 SYT7 SYT9 SYTL1 SYTL2 SYTL3
Entrez ID		22895	9378
HPRD ID		15273	11858
Ensembl ID		ENSG00000089169	ENSG00000179915
Uniprot IDs		A0A024RBK6 Q9Y2J0	A0A0D9SEM5 A0A0D9SEQ7 A0A1D5RMU6 E7EQN4 E7ERL8 H0Y568 H7BYC7 P58400 Q9ULB1
PDB IDs			3B3Q 5Z8Y
Enriched GO Terms of Interacting Partners?
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