NRXN1 and SYT7

Number of citations of the paper that reports this interaction (PubMedID 8901523)
6

Data Source:
HPRD (in vitro)

		NRXN1	SYT7
Description		neurexin 1	synaptotagmin 7
Image
GO Annotations	Cellular Component	Nucleolus Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Cell Junction Nuclear Membrane Vesicle Protein-containing Complex Presynaptic Membrane Cell Projection Neuronal Cell Body Schaffer Collateral - CA1 Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Active Zone Membrane	Lysosome Lysosomal Membrane Peroxisome Peroxisomal Membrane Cytosol Plasma Membrane Synaptic Vesicle Cell Junction Dendrite Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Early Phagosome Neuronal Cell Body Axon Terminus Extracellular Exosome Exocytic Vesicle Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Acetylcholine Receptor Binding Signaling Receptor Activity Cell Adhesion Molecule Binding Neuroligin Family Protein Binding	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Syntaxin Binding Clathrin Binding
	Biological Process	Neuron Cell-cell Adhesion Chemical Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Adult Behavior Social Behavior Vocal Learning Neuromuscular Process Controlling Balance Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Vocalization Behavior Positive Regulation Of Synapse Maturation Postsynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Regulation Of Synaptic Vesicle Cycle Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Endocannabinoid Synaptic Membrane Adhesion Regulation Of Presynapse Assembly Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Grooming Behavior	Plasma Membrane Repair Phagocytosis Regulation Of Dopamine Secretion Vesicle-mediated Transport Calcium Ion Regulated Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Recycling Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Bone Remodeling Calcium Ion-regulated Exocytosis Of Neurotransmitter Regulation Of Phagocytosis Regulation Of Insulin Secretion Regulation Of Glucagon Secretion Cellular Response To Calcium Ion Vesicle-mediated Cholesterol Transport Phagosome-lysosome Fusion Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Synaptic Vesicle Endocytosis Short-term Synaptic Potentiation Calcium Ion Regulated Lysosome Exocytosis
Pathways		Neurexins and neuroligins Neurexins and neuroligins Non-integrin membrane-ECM interactions Neurexins and neuroligins Neurexins and neuroligins	Neurexins and neuroligins
Drugs		Calcium Citrate Calcium Phosphate
Diseases		Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
GWAS		Body mass index ( 28892062) Chromosomal aberration frequency (chromatid type) ( 31586183) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Educational attainment ( 25201988) General risk tolerance (MTAG) ( 30643258) Isovolumetric relaxation time ( 28394258) Lateral ventricle temporal horn volume ( 31530798) Longevity ( 20834067) Lung cancer in ever smokers ( 28604730) Metabolite levels (HVA/MHPG ratio) ( 23319000) Morning person ( 30696823) Personality dimensions ( 20691247) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive astigmatism ( 25367360) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Severe gingival inflammation ( 28459102) Systolic blood pressure ( 30224653 30578418) Temperament ( 22832960) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Word spelling ( 30741946)	Intelligence (MTAG) ( 29326435) Mean arterial pressure ( 26390057) Metabolite levels ( 23823483) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311)
Interacting Genes		29 interacting genes: AFDN APBA1 APBA2 ATP13A2 CASK MACF1 MYO16 NLGN1 NLGN2 NLGN3 NXPH1 NXPH2 NXPH3 PDZD2 RPH3A RTN4 SDCBP2 SIPA1L1 SYT1 SYT13 SYT2 SYT4 SYT5 SYT6 SYT7 SYT9 SYTL1 SYTL2 SYTL3	8 interacting genes: AP2A1 NRXN1 SIAH1 STX1A STX2 STX3 STX4 SYNCRIP
Entrez ID		9378	9066
HPRD ID		11858	11965
Ensembl ID		ENSG00000179915	ENSG00000011347
Uniprot IDs		A0A0D9SEM5 A0A0D9SEQ7 A0A1D5RMU6 E7EQN4 E7ERL8 H0Y568 H7BYC7 P58400 Q9ULB1	O43581
PDB IDs		3B3Q 5Z8Y	2D8K
Enriched GO Terms of Interacting Partners?
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