DIS3 and EXOSC8

Number of citations of the paper that reports this interaction (PubMedID 11719186)
341

Data Source:
BioGRID (two hybrid)
HPRD (in vivo)

		DIS3	EXOSC8
Description		DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease	exosome component 8
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol Membrane	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Endonuclease Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	Exoribonuclease Activity Protein Binding AU-rich Element Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding
	Biological Process	RRNA Processing RRNA Catabolic Process Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay CUT Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Biological_process RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent MRNA Catabolic Process
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Restless legs syndrome ( 29029846)
Interacting Genes		12 interacting genes: EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MPP6 MTREX NTMT1 ZBTB17	49 interacting genes: AEN ATF2 CAB39L COL23A1 COX5A CRMP1 CWC22 DIS3 DUSP23 EEF1DP3 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM90A1 FHOD1 FOXN3 FRG1 LSM1 LSM7 MAPK8IP1 MKRN1 MORN4 MPHOSPH6 MPP6 MTREX N4BP2L2 OTUD4 PDCD1LG2 RASSF1 REL RERG RPP14 RXRB SNRPB SNRPC TCEA2 TFAP4 TXNDC17 TXNDC9 UBC UPF2 USP6 XRN1 XRN2 ZFP36
Entrez ID		22894	11340
HPRD ID		06338	09351
Ensembl ID		ENSG00000083520	ENSG00000120699
Uniprot IDs		G3V1J5 Q9Y2L1	Q96B26
PDB IDs		6D6Q 6D6R 6H25	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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