DIS3 and MPP6

Number of citations of the paper that reports this interaction (PubMedID 11719186)
341

Data Source:
HPRD (in vivo)

		DIS3	MPP6
Description		DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease	membrane palmitoylated protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol Membrane	Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Endonuclease Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding
	Biological Process	RRNA Processing RRNA Catabolic Process Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay CUT Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Protein-containing Complex Assembly
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Restless legs syndrome ( 29029846)	Bipolar disorder ( 31043756) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Fasting glucose change (long-term) ( 31263163) Schizophrenia ( 29483656) Urate levels in obese individuals ( 25811787)
Interacting Genes		12 interacting genes: EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MPP6 MTREX NTMT1 ZBTB17	28 interacting genes: AATF ABCA1 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A MT2P1 MTREX NDN NFKB1 PARN RPS20 SMARCA4 SNX9 THOP1
Entrez ID		22894	51678
HPRD ID		06338	09509
Ensembl ID		ENSG00000083520	ENSG00000105926
Uniprot IDs		G3V1J5 Q9Y2L1	A0A024RA25 B8ZZG1 Q9NZW5
PDB IDs		6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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