EXOSC8 and N4BP2L2

		EXOSC8	N4BP2L2
Description		exosome component 8	NEDD4 binding protein 2 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle	Nucleus Transcriptional Repressor Complex Extracellular Exosome
	Molecular Function	Exoribonuclease Activity Protein Binding AU-rich Element Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding	Molecular_function Transcription Corepressor Activity Protein Binding Enzyme Binding
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Biological_process RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent MRNA Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Breast cancer ( 23535729) Coronary artery disease ( 29212778) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Logical memory (delayed recall) ( 29274321)
Interacting Genes		49 interacting genes: AEN ATF2 CAB39L COL23A1 COX5A CRMP1 CWC22 DIS3 DUSP23 EEF1DP3 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM90A1 FHOD1 FOXN3 FRG1 LSM1 LSM7 MAPK8IP1 MKRN1 MORN4 MPHOSPH6 MPP6 MTREX N4BP2L2 OTUD4 PDCD1LG2 RASSF1 REL RERG RPP14 RXRB SNRPB SNRPC TCEA2 TFAP4 TXNDC17 TXNDC9 UBC UPF2 USP6 XRN1 XRN2 ZFP36	6 interacting genes: EXOSC8 HOXA1 LMO2 NAA38 PPIA PPIH
Entrez ID		11340	10443
HPRD ID		09351	15119
Ensembl ID		ENSG00000120699	ENSG00000244754
Uniprot IDs		Q96B26	A0A024RDV2 B4DPY1 Q92802 Q9Y3H6
PDB IDs		2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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