F12 and APOH

Number of citations of the paper that reports this interaction (PubMedID 3361230)
3

Data Source:
HPRD (in vitro)

		F12	APOH
Description		coagulation factor XII	apolipoprotein H
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Rough Endoplasmic Reticulum Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Cell Surface Platelet Dense Granule Lumen Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Misfolded Protein Binding	Protein Binding Phospholipid Binding Heparin Binding Lipid Binding Identical Protein Binding Lipoprotein Lipase Activator Activity
	Biological Process	Plasma Kallikrein-kinin Cascade Factor XII Activation Proteolysis Blood Coagulation, Intrinsic Pathway Positive Regulation Of Plasminogen Activation Protein Processing Protein Autoprocessing Positive Regulation Of Blood Coagulation Zymogen Activation Fibrinolysis Innate Immune Response Response To Misfolded Protein Positive Regulation Of Fibrinolysis	Negative Regulation Of Endothelial Cell Proliferation Platelet Degranulation Triglyceride Metabolic Process Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Plasminogen Activation Negative Regulation Of Myeloid Cell Apoptotic Process Triglyceride Transport Negative Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Lipoprotein Lipase Activity Regulation Of Fibrinolysis Negative Regulation Of Fibrinolysis
Pathways		Intrinsic Pathway of Fibrin Clot Formation	Platelet degranulation
Drugs		Zinc Human C1-esterase inhibitor Ethanolamine Oleate Conestat alfa Nafamostat	LJP 1082 Copper
Diseases		Factor XII deficiency; Hageman factor deficiency Hereditary angioedema
GWAS		Activated partial thromboplastin time ( 22703881 29403010 20303064) Blood metabolite ratios ( 24816252) Blood protein levels ( 29875488 28240269) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Circulating chromogranin peptide levels ( 28011710) Circulating vasoactive peptide levels ( 23381795) Glycine levels ( 30837465) L-arginine levels ( 27656708) Metabolite levels ( 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Nephrolithiasis ( 22396660) Platelet function and related traits ( 21546496) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) Activated partial thromboplastin time ( 29403010) Blood pressure measurement (high sodium and potassium intervention) ( 24165912) Blood protein levels ( 30072576 29875488 28240269) Cardiometabolic and hematological traits ( 27668658) Coronary artery disease ( 29212778) Creatine kinase levels ( 29403010) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Platelet count ( 27863252) Plateletcrit ( 27863252) Presence of antiphospholipid antibodies ( 27098658) Systolic blood pressure ( 30224653) Triglycerides ( 30275531)
Interacting Genes		16 interacting genes: APOH APP CD93 EPAS1 GP1BA HIF1A KLKB1 KRT1 MMP12 MMP13 MMP14 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2N	14 interacting genes: AKT1 ANXA2 CDC42 CLEC4G F10 F12 GEM GRB2 LPA LRP2 LRP8 PLG RBBP6 TP53
Entrez ID		2161	350
HPRD ID		01992	00728
Ensembl ID		ENSG00000131187	ENSG00000091583
Uniprot IDs		P00748 Q8IZZ5	A0A384NKM6 P02749
PDB IDs		4BDW 4BDX 4XDE 4XE4 6B74 6B77 6GT6 6QF7	1C1Z 1G4F 1G4G 1QUB 2KRI 3OP8 4JHS
Enriched GO Terms of Interacting Partners?
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