AK1 and TRIM63

Number of citations of the paper that reports this interaction (PubMedID 15967462)
98

Data Source:
BioGRID (two hybrid)

		AK1	TRIM63
Description		adenylate kinase 1	tripartite motif containing 63
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Nucleus Cytoplasm Microtubule Z Disc M Band
	Molecular Function	Adenylate Kinase Activity Nucleoside Diphosphate Kinase Activity ATP Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Titin Binding
	Biological Process	Nucleoside Diphosphate Phosphorylation ADP Biosynthetic Process Nucleoside Triphosphate Biosynthetic Process Nucleobase-containing Small Molecule Interconversion AMP Metabolic Process ATP Metabolic Process Nucleoside Monophosphate Phosphorylation	Muscle Contraction Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Response To Glucocorticoid Response To Interleukin-1
Pathways		Interconversion of nucleotide di- and triphosphates	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Bis(Adenosine)-5'-Pentaphosphate
Diseases		Anemia due to disorders of nucleotide metabolism, including: Adenylate kinase (AK) deficiency; Uridine 5-prime monophosphate hydrolase (UMPH1) deficiency
GWAS		Blood protein levels ( 30072576) Body mass index ( 26426971) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Red blood cell count ( 27863252)
Interacting Genes		6 interacting genes: APP FHL2 TERF1 TERF2IP TINF2 TRIM63	93 interacting genes: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5F1B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH HSPD1 JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYH6 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP THRA TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2J1 UBE2K UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1
Entrez ID		203	84676
HPRD ID		00046	05843
Ensembl ID		ENSG00000106992	ENSG00000158022
Uniprot IDs		P00568 Q5T9B7 Q6FGX9	Q969Q1
PDB IDs		1Z83 2C95	2D8U 3DDT 4M3L
Enriched GO Terms of Interacting Partners?
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