AHR and XPO1

Number of citations of the paper that reports this interaction (PubMedID 12065584)
6

Data Source:
HPRD (in vivo, in vitro)

		AHR	XPO1
Description		aryl hydrocarbon receptor	exportin 1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Protein-containing Complex Cytosolic Aryl Hydrocarbon Receptor Complex	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Host Cell Ribonucleoprotein Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TFIID-class Transcription Factor Complex Binding Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding TBP-class Protein Binding Enhancer Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity Hsp90 Protein Binding E-box Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Nuclear Export Signal Receptor Activity Protein Binding Ran GTPase Binding Protein Domain Specific Binding
	Biological Process	Blood Vessel Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Xenobiotic Metabolic Process Apoptotic Process Cell Cycle Response To Xenobiotic Stimulus Response To Toxic Substance Regulation Of Gene Expression CAMP-mediated Signaling Intracellular Receptor Signaling Pathway Regulation Of B Cell Proliferation Circadian Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To CAMP Cellular Response To Forskolin Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Transcription By RNA Polymerase II Protein Export From Nucleus Nucleocytoplasmic Transport Regulation Of Centrosome Duplication Viral Process Protein Localization To Nucleus Regulation Of Protein Catabolic Process Ribosome Biogenesis Response To Drug Regulation Of MRNA Stability Regulation Of Protein Export From Nucleus MRNA Transport Intracellular Transport Of Virus
Pathways		PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation
Drugs		Omeprazole Mexiletine Nimodipine Flutamide Atorvastatin Leflunomide Ginseng Indirubin-3'-Monoxime Resveratrol Quercetin beta-Naphthoflavone Emodin BENZOTHIAZOLE Diosmin Indigotindisulfonic Acid Kynurenic Acid Epigallocatechin Gallate Cantharidin Indirubin
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Blood metabolite levels ( 24816252) Caffeine consumption ( 21490707) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Coffee consumption ( 31345160 21357676 29367735 31046077 25288136) Coffee consumption (cups per day) ( 25288136) Cutaneous squamous cell carcinoma ( 27424798) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 26192919) Lung cancer in ever smokers ( 28604730) Metabolic traits ( 21886157) Microalbuminuria ( 31511532) Plasma kynurenine levels in major depressive disorder ( 29317604) Rosacea symptom severity ( 29771307) Severe influenza A (H1N1) infection ( 26379185) Sweet beverage consumption ( 31046077) Tea consumption ( 31046077) Ulcerative colitis ( 26192919) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 30910378 31511532) Urinary potassium excretion ( 31409800) Urinary sodium excretion ( 31409800)	Atrial fibrillation ( 29892015) Eosinophil counts ( 27863252) Erectile dysfunction ( 30583798) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Urinary sodium excretion ( 31409800)
Interacting Genes		35 interacting genes: AIP AR ARNT ARNT2 ARNTL BRCA1 CCNT1 CUL4B DAP3 EP300 ESR1 GTF2F1 GTF2F2 HSP90AA1 IVNS1ABP NCOA1 NCOA2 NCOA7 NCOR2 NEDD8 NR2F1 NRIP1 PTGES3 RB1 RELA SMARCA4 SP1 STUB1 TAF4 TAF6 TAF7 TAF9 TBL3 TBP XPO1	77 interacting genes: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 BRCA2 CCND1 CDC25A CDCA4 CDKN1B CHEK1 CHORDC1 CIITA CRK DDX3X DESI1 DR1 E2F4 E2F5 EIF5A ERF FBXO7 FOXO4 HDAC3 HNF4A HSPA9 HSPB1 IRF5 KIF17 MAPK6 NF2 NMD3 NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 ORC1 PHAX PHB PKIA RAD51 RAN RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SMURF2 SNUPN SOX2 STAT1 STRADA SUMO1 TERF2IP TERT TOP2A TOP2B TP53 TP73
Entrez ID		196	7514
HPRD ID		02596	03975
Ensembl ID		ENSG00000106546	ENSG00000082898
Uniprot IDs		A0A024R9Z8 P35869	B3KWD0 O14980
PDB IDs		5NJ8	1W9C 2L1L 3GB8 4BSM 4BSN 5DIS
Enriched GO Terms of Interacting Partners?
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