DNMT3A and EED

Number of citations of the paper that reports this interaction (PubMedID 16357870)
737

Data Source:
BioGRID (imaging technique)
HPRD (in vitro)

		DNMT3A	EED
Description		DNA methyltransferase 3 alpha	embryonic ectoderm development
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Euchromatin XY Body Nucleus Nucleoplasm Nuclear Heterochromatin Cytoplasm Nuclear Matrix	Sex Chromatin Nucleus Nucleoplasm Cytosol ESC/E(Z) Complex Pronucleus
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA Binding Chromatin Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding Transcription Factor Binding DNA-methyltransferase Activity Identical Protein Binding Metal Ion Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Protein Binding Nucleosome Binding Histone Methyltransferase Activity Identical Protein Binding Histone Methyltransferase Activity (H3-K27 Specific)
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle DNA Methylation Methylation-dependent Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Spermatogenesis Aging Response To Ionizing Radiation Response To Lead Ion Positive Regulation Of Cell Death Neuron Differentiation Response To Estradiol Response To Vitamin A Response To Cocaine DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Negative Regulation Of Gene Expression, Epigenetic Cellular Response To Amino Acid Stimulus Cellular Response To Ethanol Cellular Response To Hypoxia C-5 Methylation Of Cytosine Hepatocyte Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Viral Process Spinal Cord Development Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Oligodendrocyte Differentiation Positive Regulation Of Histone H3-K27 Methylation Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation Cellular Response To Leukemia Inhibitory Factor Regulation Of Adaxial/abaxial Pattern Formation
Pathways		PRC2 methylates histones and DNA RMTs methylate histone arginines SUMOylation of DNA methylation proteins DNA methylation	PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Heel bone mineral density ( 30598549) Height ( 28552196 25282103 25429064 31562340 18391951) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Macular thickness ( 30535121) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 27863252) Resistant hypertension ( 31545351) Type 1 diabetes ( 21980299) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		30 interacting genes: CBX1 DDB1 DNMT1 DNMT3B DNMT3L EED EHMT1 EHMT2 EZH2 F8A1 H3C1 H3C6 HDAC1 MYC NRIP1 PIAS1 PIAS2 PRMT5 PTGES3 SETDB1 SP100 SPI1 SUV39H1 TCL1A TERF2IP UBE2I UHRF1 USP7 ZBTB17 ZBTB18	39 interacting genes: AEBP2 ANXA5 BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FHL1 H1-1 H3C1 HDAC1 HDAC2 HDAC3 ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PJA1 PPP1CA PPP1R8 PRDM14 RACK1 RPS10 SELENBP1 SMYD3 SRPK2 TGS1 TSC22D1 UBE2W YY1 ZBED8 ZFP42
Entrez ID		1788	8726
HPRD ID		04141	09343
Ensembl ID		ENSG00000119772	ENSG00000074266
Uniprot IDs		A0A0C4DG02 F8WE91 Q59HC6 Q9Y6K1	E9PJK2 O75530
PDB IDs		2QRV 3A1A 3A1B 3LLR 3SVM 4QBQ 4QBR 4QBS 4U7P 4U7T 5YX2 6BRR 6F57	3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27 4W2R 4X3E 5GSA 5H13 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5K0M 5LS6 5TTW 5U5H 5U5K 5U5T 5U62 5U69 5U6D 5U8A 5U8F 5WG6 5WP3 5WUK 6B3W 6C23 6C24 6SFB 6SFC
Enriched GO Terms of Interacting Partners?
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