EED and DUSP23

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		EED	DUSP23
Description		embryonic ectoderm development	dual specificity phosphatase 23
Image
GO Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Cytosol ESC/E(Z) Complex Pronucleus	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Protein Binding Nucleosome Binding Histone Methyltransferase Activity Identical Protein Binding Histone Methyltransferase Activity (H3-K27 Specific)	Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Viral Process Spinal Cord Development Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Oligodendrocyte Differentiation Positive Regulation Of Histone H3-K27 Methylation Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation Cellular Response To Leukemia Inhibitory Factor Regulation Of Adaxial/abaxial Pattern Formation	Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events
Drugs			4-Nitrophenyl Phosphate
Diseases
GWAS		Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)	Bone mineral density (Ward's triangle area) ( 27397699) C-reactive protein ( 22939635) Interstitial lung disease ( 21787189)
Interacting Genes		39 interacting genes: AEBP2 ANXA5 BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FHL1 H1-1 H3C1 HDAC1 HDAC2 HDAC3 ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PJA1 PPP1CA PPP1R8 PRDM14 RACK1 RPS10 SELENBP1 SMYD3 SRPK2 TGS1 TSC22D1 UBE2W YY1 ZBED8 ZFP42	24 interacting genes: ASB13 CCDC186 CEP126 DBI DBN1 DNMT3B EDRF1 EED EXOSC8 GCM1 KAT5 KBTBD7 MKRN1 MRPL20 MTFR1 NIF3L1 PRDX4 RPL8 RUFY2 SHC1 SMPD1 TMOD3 TUBA1A ZNF746
Entrez ID		8726	54935
HPRD ID		09343	07908
Ensembl ID		ENSG00000074266	ENSG00000158716
Uniprot IDs		E9PJK2 O75530	A0A140VJI5 Q9BVJ7
PDB IDs		3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27 4W2R 4X3E 5GSA 5H13 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5K0M 5LS6 5TTW 5U5H 5U5K 5U5T 5U62 5U69 5U6D 5U8A 5U8F 5WG6 5WP3 5WUK 6B3W 6C23 6C24 6SFB 6SFC	2IMG 4ERC
Enriched GO Terms of Interacting Partners?
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