EED and TGS1

Number of citations of the paper that reports this interaction (PubMedID 12943661)
9

Data Source:
BioGRID (pull down, two hybrid)
HPRD (in vitro, two hybrid)

		EED	TGS1
Description		embryonic ectoderm development	trimethylguanosine synthase 1
Image
GO Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Cytosol ESC/E(Z) Complex Pronucleus	Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Small Nuclear Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Protein Binding Nucleosome Binding Histone Methyltransferase Activity Identical Protein Binding Histone Methyltransferase Activity (H3-K27 Specific)	Protein Binding RNA Methyltransferase Activity RNA Trimethylguanosine Synthase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Viral Process Spinal Cord Development Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Oligodendrocyte Differentiation Positive Regulation Of Histone H3-K27 Methylation Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation Cellular Response To Leukemia Inhibitory Factor Regulation Of Adaxial/abaxial Pattern Formation	Spliceosomal SnRNP Assembly 7-methylguanosine RNA Capping Regulation Of Lipid Metabolic Process Ribonucleoprotein Complex Biogenesis 7-methylguanosine Cap Hypermethylation
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression snRNP Assembly PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock
Drugs
Diseases
GWAS		Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)	Gut microbiota (bacterial taxa) ( 27723756) Height ( 18391951) Serum thyroid-stimulating hormone levels ( 24852370)
Interacting Genes		39 interacting genes: AEBP2 ANXA5 BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FHL1 H1-1 H3C1 HDAC1 HDAC2 HDAC3 ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PJA1 PPP1CA PPP1R8 PRDM14 RACK1 RPS10 SELENBP1 SMYD3 SRPK2 TGS1 TSC22D1 UBE2W YY1 ZBED8 ZFP42	6 interacting genes: COIL CREBBP EED EP300 HNF4A NCOA6
Entrez ID		8726	96764
HPRD ID		09343	07567
Ensembl ID		ENSG00000074266	ENSG00000137574
Uniprot IDs		E9PJK2 O75530	Q96RS0
PDB IDs		3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27 4W2R 4X3E 5GSA 5H13 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5K0M 5LS6 5TTW 5U5H 5U5K 5U5T 5U62 5U69 5U6D 5U8A 5U8F 5WG6 5WP3 5WUK 6B3W 6C23 6C24 6SFB 6SFC	3EGI 3GDH
Enriched GO Terms of Interacting Partners?
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