USP54 and ARID5B

		USP54	ARID5B
Description		ubiquitin specific peptidase 54	AT-rich interaction domain 5B
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm
	Molecular Function	Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Transcription Coactivator Activity Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process	Protein Deubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Liver Development Regulation Of Transcription By RNA Polymerase II Nitrogen Compound Metabolic Process Male Gonad Development Female Gonad Development Post-embryonic Development Fibroblast Migration Adrenal Gland Development Multicellular Organism Growth Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Platelet-derived Growth Factor Receptor Signaling Pathway Cell Development Muscle Organ Morphogenesis Skeletal System Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Roof Of Mouth Development Face Morphogenesis Adipose Tissue Development Fat Pad Development Positive Regulation Of Nucleic Acid-templated Transcription Cellular Response To Leukemia Inhibitory Factor
Pathways			HDMs demethylate histones
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 29348612 28817678 22076464 25310577 23512250 19684603 19684604) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) Automobile speeding propensity ( 30643258) B-cell acute lymphoblastic leukaemia ( 31767839) Blood urea nitrogen levels ( 31152163) Central corneal thickness ( 31798171 29760442 30894546) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Corneal resistance factor ( 30894546) Corneal structure ( 23291589) Diastolic blood pressure ( 19430483) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Height ( 31562340) Intraocular pressure ( 29617998 29235454) Intraocular pressure (Goldman correlated) ( 30894546) Medication use (thyroid preparations) ( 31015401) Plateletcrit ( 27863252) Reaction time ( 29844566) Response to haloperidol in psychosis ( 24751813) Rheumatoid arthritis ( 30423114 22446963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Serum total protein level ( 23022100) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systemic lupus erythematosus ( 27399966 23273568 26502338) Vitiligo ( 27723757)
Interacting Genes		21 interacting genes: ARID5B ATN1 ATXN1 CDK19 CFAP70 CHMP1B CHMP2A CHMP2B CHMP4C COMTD1 EIF4E2 FAM149B1 FUT11 HK1 MSS51 MSX2 NXT2 PLCD1 SAMD8 TTYH1 UBC	1 interacting genes: USP54
Entrez ID		159195	84159
HPRD ID		15641	18880
Ensembl ID		ENSG00000166348	ENSG00000150347
Uniprot IDs		B7Z7X1 Q70EL1	Q14865
PDB IDs			1IG6 2OEH
Enriched GO Terms of Interacting Partners?
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