TRIM69 and KRT17

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TRIM69	KRT17
Description		tripartite motif containing 69	keratin 17
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Nuclear Speck	Cytosol Intermediate Filament Intermediate Filament Cytoskeleton Extracellular Exosome Cell Periphery
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding	Structural Constituent Of Cytoskeleton Protein Binding MHC Class II Receptor Activity MHC Class II Protein Binding
	Biological Process	Protein Polyubiquitination Apoptotic Process	Signal Transduction Epidermis Development Positive Regulation Of Cell Growth Hair Follicle Morphogenesis Keratinization Intermediate Filament Organization Positive Regulation Of Translation Positive Regulation Of Hair Follicle Development Cornification
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Keratinization Formation of the cornified envelope
Drugs
Diseases			Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS		Estimated glomerular filtration rate in non-diabetics ( 31451708)
Interacting Genes		28 interacting genes: APP ASNS ATP5MC1 DVL1 FAM110A FKBP1B HAUS1 HGS IYD KRT17 LARP1B MAGEA4 NEK8 PML PPP1R18 RECK RSPH14 SF1 SF3A3 SKIL SYNE4 TRIM44 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N ZNF483	10 interacting genes: APC CCDC85B EGFR HRAS KDM1A KRT6A KRT7 KRT72 TRIM69 ZDHHC17
Entrez ID		140691	3872
HPRD ID		11518	01019
Ensembl ID		ENSG00000185880	ENSG00000128422
Uniprot IDs		H0YL66 Q86WT6	Q04695 Q14666
PDB IDs		4NQJ
Enriched GO Terms of Interacting Partners?
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