SENP8 and COPS2

Number of citations of the paper that reports this interaction (PubMedID 23408908)
16

Data Source:
BioGRID (affinity chromatography technology, far western blotting)

		SENP8	COPS2
Description		SUMO peptidase family member, NEDD8 specific	COP9 signalosome subunit 2
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GO Annotations	Cellular Component	Cytosol	Nucleoplasm Cytoplasm Cytosol COP9 Signalosome
	Molecular Function	NEDD8-specific Protease Activity	Transcription Corepressor Activity Protein Binding
	Biological Process	Protein Deubiquitination Post-translational Protein Modification	Negative Regulation Of Transcription By RNA Polymerase II Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Inner Cell Mass Cell Proliferation Transcription-coupled Nucleotide-excision Repair Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Neuron Differentiation Skeletal Muscle Cell Differentiation Post-translational Protein Modification Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		UCH proteinases Neddylation	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Metabolite levels (HVA/MHPG ratio) ( 23319000)	Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		13 interacting genes: COPS2 CUL1 CUL2 CUL4A GPS1 NEDD8 PLA2G2A SMURF1 TERF1 UBE2M USP15 USP21 USP28	35 interacting genes: COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CUL1 CUL5 DDB1 EP300 GFER GPS1 H3C1 H4C1 ING1 ING2 IP6K1 IRF8 MAP3K10 MAPK8 NCOR1 NIF3L1 NR0B1 NR2F1 PRKD1 RARA RXRA SENP8 SIN3A SIN3B THRA THRB TP53 VDR
Entrez ID		123228	9318
HPRD ID		09784	05146
Ensembl ID		ENSG00000166192	ENSG00000166200
Uniprot IDs		A8K8D3 Q96LD8	P61201 Q59EL2
PDB IDs		1XT9 2BKQ 2BKR	4D10 4D18 4WSN 6A73 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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