GPRASP2 and CHRM2

Number of citations of the paper that reports this interaction (PubMedID 15086532)
34

Data Source:
HPRD (in vitro)

		GPRASP2	CHRM2
Description		G protein-coupled receptor associated sorting protein 2	cholinergic receptor muscarinic 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cell Junction Dendrite Clathrin-coated Vesicle Membrane Asymmetric Synapse Symmetric Synapse Neuronal Cell Body Axon Terminus Synapse Glutamatergic Synapse Cholinergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Amyloid-beta Binding G Protein-coupled Receptor Binding Protein Binding	G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity Arrestin Family Protein Binding
	Biological Process		Regulation Of Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Nervous System Development Regulation Of Heart Contraction Response To Virus Membrane Organization G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis
Pathways			Muscarinic acetylcholine receptors G alpha (i) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Succinylcholine Ziprasidone Disopyramide Amitriptyline Ipratropium bromide Olanzapine Metixene Terfenadine Clozapine Trihexyphenidyl Oxyphencyclimine Procyclidine Ethopropazine Loxapine Carbachol Promazine Hyoscyamine Cyproheptadine Pethidine Imipramine Methylscopolamine bromide Gallamine Triethiodide Darifenacin Tridihexethyl Triflupromazine Anisotropine Methylbromide Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine Methylbromide Trimipramine Rocuronium Scopolamine Benzquinamide Propiomazine Cryptenamine Dicyclomine Tropicamide Brompheniramine Cocaine Maprotiline Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Diphenhydramine Pilocarpine Doxacurium chloride Doxepin Flavoxate Desipramine Ketamine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Metocurine Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Acetylcholine ALKS 27 Fesoterodine Hexocyclium Dimetindene Aclidinium Umeclidinium Dosulepin Etoperidone Imidafenacin Butylscopolamine
Diseases
GWAS			Copper levels ( 26025379) General risk tolerance (MTAG) ( 30643258) Heart rate ( 23583979) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Pulse pressure ( 30224653) Resting heart rate ( 29769521 27798624)
Interacting Genes		29 interacting genes: ADRB1 ARHGEF6 BARD1 CALCR CBX8 CEP126 CFAP206 CHRM1 CHRM2 DISC1 FRAT1 HAP1 HRH2 HTR7 HTT LRIF1 MICU2 MYOT NOL4L-DT PRPF3 PTN RPS6KA5 RTL10 STMN2 TCF25 TSPOAP1 TXN TXN2 ZNF688	10 interacting genes: GNA11 GNA14 GNA15 GNG2 GPRASP1 GPRASP2 GRK5 RGS7 SAG SET
Entrez ID		114928	1129
HPRD ID		06612	00328
Ensembl ID		ENSG00000158301	ENSG00000181072
Uniprot IDs		B3KW05 Q96D09	A4D1Q0 P08172 Q6SL56 Q6SL59 Q86SJ1
PDB IDs			1LUB 3UON 4MQS 4MQT 5YC8 5ZK3 5ZK8 5ZKB 5ZKC 6OIK
Enriched GO Terms of Interacting Partners?
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