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BRCA1 |
BRCA1 DNA repair associated |
- Meiotic synapsis
- SUMOylation of DNA damage response and repair proteins
- HDR through Single Strand Annealing (SSA)
- HDR through Homologous Recombination (HRR)
- Metalloprotease DUBs
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Nonhomologous End-Joining (NHEJ)
- Homologous DNA Pairing and Strand Exchange
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- TP53 Regulates Transcription of DNA Repair Genes
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Transcriptional Regulation by E2F6
- Meiotic recombination
- Defective DNA double strand break response due to BRCA1 loss of function
- Defective DNA double strand break response due to BARD1 loss of function
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- Breast cancer
- Ovarian cancer
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APC |
APC regulator of WNT signaling pathway |
- Apoptotic cleavage of cellular proteins
- Degradation of beta-catenin by the destruction complex
- Beta-catenin phosphorylation cascade
- Deactivation of the beta-catenin transactivating complex
- Disassembly of the destruction complex and recruitment of AXIN to the membrane
- Disassembly of the destruction complex and recruitment of AXIN to the membrane
- Signaling by GSK3beta mutants
- S33 mutants of beta-catenin aren't phosphorylated
- S37 mutants of beta-catenin aren't phosphorylated
- S45 mutants of beta-catenin aren't phosphorylated
- T41 mutants of beta-catenin aren't phosphorylated
- APC truncation mutants are not K63 polyubiquitinated
- APC truncation mutants have impaired AXIN binding
- AXIN missense mutants destabilize the destruction complex
- Truncations of AMER1 destabilize the destruction complex
- Ovarian tumor domain proteases
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- Familial adenomatous polyposis
- Esophageal cancer
- Gastric cancer
- Cancer of the anal canal
- Gallbladder cancer
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GNAI2 |
G protein subunit alpha i2 |
- PLC beta mediated events
- PLC beta mediated events
- Adenylate cyclase inhibitory pathway
- Adenylate cyclase inhibitory pathway
- G-protein activation
- ADP signalling through P2Y purinoceptor 12
- Adrenaline,noradrenaline inhibits insulin secretion
- Adrenaline,noradrenaline inhibits insulin secretion
- G alpha (s) signalling events
- G alpha (i) signalling events
- G alpha (i) signalling events
- G alpha (z) signalling events
- Regulation of insulin secretion
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
- Extra-nuclear estrogen signaling
- ADORA2B mediated anti-inflammatory cytokines production
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MYC |
MYC proto-oncogene, bHLH transcription factor |
- Transcription of E2F targets under negative control by DREAM complex
- NOTCH1 Intracellular Domain Regulates Transcription
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Binding of TCF/LEF:CTNNB1 to target gene promoters
- MAPK6/MAPK4 signaling
- Ub-specific processing proteases
- Interleukin-4 and Interleukin-13 signaling
- Cyclin E associated events during G1/S transition
- Cyclin A:Cdk2-associated events at S phase entry
- TFAP2 (AP-2) family regulates transcription of cell cycle factors
- RUNX3 regulates WNT signaling
- Estrogen-dependent gene expression
- Transcriptional regulation of granulopoiesis
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- Acetylsalicylic acid
- Nadroparin
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- Choriocarcinoma
- Penile cancer
- Burkitt lymphoma
- Oral cancer
- Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
- Multiple myeloma
- Small cell lung cancer
- Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
- Osteosarcoma
- Kaposi's sarcoma
- Laryngeal cancer
- Breast cancer
- Ovarian cancer
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SUMO2 |
small ubiquitin like modifier 2 |
- Vitamin D (calciferol) metabolism
- SUMO is conjugated to E1 (UBA2:SAE1)
- SUMO is transferred from E1 to E2 (UBE2I, UBC9)
- SUMO is proteolytically processed
- SUMOylation of DNA damage response and repair proteins
- SUMOylation of transcription factors
- SUMOylation of transcription cofactors
- SUMOylation of SUMOylation proteins
- SUMOylation of intracellular receptors
- SUMOylation of intracellular receptors
- SUMOylation of chromatin organization proteins
- SUMOylation of RNA binding proteins
- SUMOylation of DNA replication proteins
- Processing of DNA double-strand break ends
- Formation of Incision Complex in GG-NER
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YWHAG |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma |
- Activation of BAD and translocation to mitochondria
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- Regulation of PLK1 Activity at G2/M Transition
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- RHO GTPases activate PKNs
- TP53 Regulates Metabolic Genes
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
- AURKA Activation by TPX2
- Regulation of localization of FOXO transcription factors
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HDAC6 |
histone deacetylase 6 |
- NOTCH1 Intracellular Domain Regulates Transcription
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- HSF1 activation
- Notch-HLH transcription pathway
- Cilium Assembly
- Transcriptional regulation by RUNX2
- RUNX2 regulates osteoblast differentiation
- Chaperone Mediated Autophagy
- Late endosomal microautophagy
- Aggrephagy
- Aggrephagy
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- Vorinostat
- Belinostat
- Pracinostat
- Romidepsin
- Panobinostat
- Bufexamac
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B4GALT1 |
beta-1,4-galactosyltransferase 1 |
- Pre-NOTCH Processing in Golgi
- Keratan sulfate biosynthesis
- Interaction With Cumulus Cells And The Zona Pellucida
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Lactose synthesis
- Neutrophil degranulation
- N-Glycan antennae elongation
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- N-Acetylglucosamine
- 6-Aminohexyl-uridine-C1,5'-diphosphate
- 4)-N-acetyl-beta-D-glucosamine
- Galactose-uridine-5'-diphosphate
- Uridine monophosphate
- 2-(N-morpholino)ethanesulfonic acid
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- Congenital disorders of glycosylation (CDG) type II
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TCP1 |
t-complex 1 |
- Prefoldin mediated transfer of substrate to CCT/TriC
- Formation of tubulin folding intermediates by CCT/TriC
- Folding of actin by CCT/TriC
- Association of TriC/CCT with target proteins during biosynthesis
- Association of TriC/CCT with target proteins during biosynthesis
- BBSome-mediated cargo-targeting to cilium
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
- Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
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BCAR1 |
BCAR1 scaffold protein, Cas family member |
- Downstream signal transduction
- p130Cas linkage to MAPK signaling for integrins
- VEGFA-VEGFR2 Pathway
- VEGFA-VEGFR2 Pathway
- PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
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PRKN |
parkin RBR E3 ubiquitin protein ligase |
- PINK1-PRKN Mediated Mitophagy
- Josephin domain DUBs
- Aggrephagy
- Amyloid fiber formation
- Antigen processing: Ubiquitination & Proteasome degradation
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VDAC1 |
voltage dependent anion channel 1 |
- Mitochondrial protein import
- PINK1-PRKN Mediated Mitophagy
- Ub-specific processing proteases
- Pyruvate metabolism
- Mitochondrial calcium ion transport
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- Aluminium monostearate
- Cannabidiol
- Medical Cannabis
- Nabiximols
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LTA |
lymphotoxin alpha |
- TNFR2 non-canonical NF-kB pathway
- TNFs bind their physiological receptors
- TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
- TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
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RACGAP1 |
Rac GTPase activating protein 1 |
- Rho GTPase cycle
- MHC class II antigen presentation
- COPI-dependent Golgi-to-ER retrograde traffic
- Kinesins
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S100A8 |
S100 calcium binding protein A8 |
- RHO GTPases Activate NADPH Oxidases
- Regulation of TLR by endogenous ligand
- Neutrophil degranulation
- Metal sequestration by antimicrobial proteins
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- Calcium
- Zinc
- Copper
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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HSPH1 |
heat shock protein family H (Hsp110) member 1 |
- Scavenging by Class F Receptors
- Scavenging by Class F Receptors
- Regulation of HSF1-mediated heat shock response
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MAP1LC3A |
microtubule associated protein 1 light chain 3 alpha |
- Macroautophagy
- PINK1-PRKN Mediated Mitophagy
- Receptor Mediated Mitophagy
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RAB8B |
RAB8B, member RAS oncogene family |
- TBC/RABGAPs
- RAB geranylgeranylation
- RAB GEFs exchange GTP for GDP on RABs
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- Phosphoaminophosphonic acid guanylate ester
- Guanosine-5'-Diphosphate
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SIAH1 |
siah E3 ubiquitin protein ligase 1 |
- Netrin-1 signaling
- Amyloid fiber formation
- Antigen processing: Ubiquitination & Proteasome degradation
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UCHL5 |
ubiquitin C-terminal hydrolase L5 |
- Downregulation of TGF-beta receptor signaling
- UCH proteinases
- UCH proteinases
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