Search Results for: TSC1

110 interactions involving TSC1 - TSC complex subunit 1 found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
NEFL neurofilament light
  • Unblocking of NMDA receptors, glutamate binding and activation
  • Unblocking of NMDA receptors, glutamate binding and activation
  • Ras activation upon Ca2+ influx through NMDA receptor
  • RAF/MAP kinase cascade
  • Assembly and cell surface presentation of NMDA receptors
  • Negative regulation of NMDA receptor-mediated neuronal transmission
  • Long-term potentiation
  • Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
NF2 neurofibromin 2
  • Regulation of actin dynamics for phagocytic cup formation
  • RHO GTPases activate PAKs
  • Malignant pleural mesothelioma
  • Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
PATL1 PAT1 homolog 1, processing body mRNA decay factor
  • mRNA decay by 5' to 3' exoribonuclease
  • mRNA decay by 5' to 3' exoribonuclease
PATZ1 POZ/BTB and AT hook containing zinc finger 1
PITX1 paired like homeodomain 1
  • Congenital clubfoot; Congenital talipes equinovarus
PLK1 polo like kinase 1
  • Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
  • Polo-like kinase mediated events
  • Golgi Cisternae Pericentriolar Stack Reorganization
  • Golgi Cisternae Pericentriolar Stack Reorganization
  • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
  • Phosphorylation of the APC/C
  • Phosphorylation of Emi1
  • Condensation of Prophase Chromosomes
  • Separation of Sister Chromatids
  • Resolution of Sister Chromatid Cohesion
  • Regulation of PLK1 Activity at G2/M Transition
  • Activation of NIMA Kinases NEK9, NEK6, NEK7
  • Loss of Nlp from mitotic centrosomes
  • Recruitment of mitotic centrosome proteins and complexes
  • Loss of proteins required for interphase microtubule organization from the centrosome
  • Recruitment of NuMA to mitotic centrosomes
  • Anchoring of the basal body to the plasma membrane
  • RHO GTPases Activate Formins
  • Mitotic Prometaphase
  • Mitotic Metaphase/Anaphase Transition
  • Mitotic Telophase/Cytokinesis
  • Cyclin A/B1/B2 associated events during G2/M transition
  • The role of GTSE1 in G2/M progression after G2 checkpoint
  • AURKA Activation by TPX2
  • EML4 and NUDC in mitotic spindle formation
  • 3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol
  • 3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide
  • 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE
  • 1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea
  • Wortmannin
  • Fostamatinib
PLK2 polo like kinase 2
  • TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
  • CD163 mediating an anti-inflammatory response
  • Fostamatinib
POGZ pogo transposable element derived with ZNF domain
POU6F2 POU class 6 homeobox 2
PPP1R18 protein phosphatase 1 regulatory subunit 18
PPP1R32 protein phosphatase 1 regulatory subunit 32
PRMT6 protein arginine methyltransferase 6
  • RMTs methylate histone arginines
  • RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RASSF1 Ras association domain family member 1
  • Non-small cell lung cancer
  • Bladder cancer
  • Nasopharyngeal cancer
RBPMS RNA binding protein, mRNA processing factor
RDX radixin
  • Recycling pathway of L1
  • Recycling pathway of L1
  • 1D-myo-inositol 1,4,5-trisphosphate
RHEB Ras homolog, mTORC1 binding
  • Macroautophagy
  • MTOR signalling
  • mTORC1-mediated signalling
  • Energy dependent regulation of mTOR by LKB1-AMPK
  • TP53 Regulates Metabolic Genes
  • Regulation of PTEN gene transcription
  • Amino acids regulate mTORC1
  • Guanosine-5'-Triphosphate
  • Guanosine-5'-Diphosphate
RIN1 Ras and Rab interactor 1
  • RAB GEFs exchange GTP for GDP on RABs
RIN3 Ras and Rab interactor 3
  • RAB GEFs exchange GTP for GDP on RABs
SAMD11 sterile alpha motif domain containing 11
SAMD7 sterile alpha motif domain containing 7

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