SRC - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide
ANXA7	annexin A7
ARHGAP1	Rho GTPase activating protein 1	Rho GTPase cycle
ARHGAP17	Rho GTPase activating protein 17	Rho GTPase cycle
ARHGAP32	Rho GTPase activating protein 32	Rho GTPase cycle
ARHGAP35	Rho GTPase activating protein 35	Rho GTPase cycle Sema4D mediated inhibition of cell attachment and migration PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
ARR3	arrestin 3
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
ATG9A	autophagy related 9A	Macroautophagy
ATP2B4	ATPase plasma membrane Ca2+ transporting 4	Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases	Halothane Desflurane
AXL	AXL receptor tyrosine kinase	VEGFA-VEGFR2 Pathway	Fostamatinib Gilteritinib
BCAR1	BCAR1 scaffold protein, Cas family member	Downstream signal transduction p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
BCCIP	BRCA2 and CDKN1A interacting protein
BMX	BMX non-receptor tyrosine kinase	Apoptotic cleavage of cellular proteins Synthesis of PIPs at the plasma membrane	Fostamatinib Zanubrutinib
CA3	carbonic anhydrase 3	Reversible hydration of carbon dioxide	Topiramate Ethoxzolamide Sulpiride Celecoxib Benzthiazide Valdecoxib Cyclothiazide Methazolamide Acetazolamide Dorzolamide Zonisamide Diclofenamide Brinzolamide Ellagic acid Saccharin
CAV2	caveolin 2	Extra-nuclear estrogen signaling
CBLC	Cbl proto-oncogene C
CCDC180	coiled-coil domain containing 180
CCNA1	cyclin A1	G0 and Early G1 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes Telomere Extension By Telomerase Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Ub-specific processing proteases Processing of DNA double-strand break ends TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation G2 Phase Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription Cyclin A/B1/B2 associated events during G2/M transition Cyclin A/B1/B2 associated events during G2/M transition p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry
CD33	CD33 molecule	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation	Gemtuzumab ozogamicin AVE9633
CD36	CD36 molecule	Platelet degranulation Cross-presentation of particulate exogenous antigens (phagosomes) ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade PPARA activates gene expression Scavenging by Class B Receptors Scavenging by Class B Receptors Transcriptional regulation of white adipocyte differentiation Intracellular metabolism of fatty acids regulates insulin secretion MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation

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