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EMD |
emerin |
- Nuclear Envelope Breakdown
- Initiation of Nuclear Envelope (NE) Reformation
- Depolymerisation of the Nuclear Lamina
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
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- Emery-Dreifuss muscular dystrophy
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FANCC |
FA complementation group C |
- Fanconi Anemia Pathway
- TP53 Regulates Transcription of DNA Repair Genes
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FASLG |
Fas ligand |
- Caspase activation via Death Receptors in the presence of ligand
- Regulation by c-FLIP
- RIPK1-mediated regulated necrosis
- CASP8 activity is inhibited
- Interleukin-4 and Interleukin-13 signaling
- Dimerization of procaspase-8
- FasL/ CD95L signaling
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- FOXO-mediated transcription of cell death genes
- TNFs bind their physiological receptors
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- Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
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FLT3 |
fms related receptor tyrosine kinase 3 |
- PI3K Cascade
- PIP3 activates AKT signaling
- Constitutive Signaling by Aberrant PI3K in Cancer
- RAF/MAP kinase cascade
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- FLT3 Signaling
- FLT3 Signaling
- STAT5 Activation
- FLT3 mutants bind TKIs
- STAT5 activation downstream of FLT3 ITD mutants
- KW2449-resistant FLT3 mutants
- semaxanib-resistant FLT3 mutants
- crenolanib-resistant FLT3 mutants
- gilteritinib-resistant FLT3 mutants
- lestaurtinib-resistant FLT3 mutants
- midostaurin-resistant FLT3 mutants
- pexidartinib-resistant FLT3 mutants
- ponatinib-resistant FLT3 mutants
- quizartinib-resistant FLT3 mutants
- sorafenib-resistant FLT3 mutants
- sunitinib-resistant FLT3 mutants
- tandutinib-resistant FLT3 mutants
- linifanib-resistant FLT3 mutants
- tamatinib-resistant FLT3 mutants
- Signaling by FLT3 ITD and TKD mutants
- Signaling by FLT3 ITD and TKD mutants
- Negative regulation of FLT3
- FLT3 signaling through SRC family kinases
- FLT3 signaling through SRC family kinases
- FLT3 signaling by CBL mutants
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- Sorafenib
- Sunitinib
- XL999
- Tandutinib
- ABT-869
- Lestaurtinib
- Midostaurin
- Ponatinib
- Nintedanib
- Fostamatinib
- Gilteritinib
- Brigatinib
- Fedratinib
- Amuvatinib
- Quizartinib
- Pexidartinib
- Pralsetinib
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- Acute myeloid leukemia (AML)
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FOXO1 |
forkhead box O1 |
- AKT phosphorylates targets in the nucleus
- Regulation of gene expression in beta cells
- AKT-mediated inactivation of FOXO1A
- Constitutive Signaling by AKT1 E17K in Cancer
- MAPK6/MAPK4 signaling
- Interleukin-4 and Interleukin-13 signaling
- Regulation of localization of FOXO transcription factors
- FOXO-mediated transcription of cell death genes
- FOXO-mediated transcription of cell death genes
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- Regulation of FOXO transcriptional activity by acetylation
- Regulation of FOXO transcriptional activity by acetylation
- FOXO-mediated transcription of cell cycle genes
- FOXO-mediated transcription of cell cycle genes
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- Alveolar rhabdomyosarcoma
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GFAP |
glial fibrillary acidic protein |
- Nuclear signaling by ERBB4
- Chaperone Mediated Autophagy
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GJB1 |
gap junction protein beta 1 |
- Oligomerization of connexins into connexons
- Oligomerization of connexins into connexons
- Transport of connexins along the secretory pathway
- Gap junction assembly
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- Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
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HNF1A |
HNF1 homeobox A |
- Regulation of gene expression in beta cells
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- Maturity onset diabetes of the young (MODY)
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KCNA5 |
potassium voltage-gated channel subfamily A member 5 |
- Voltage gated Potassium channels
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- Enflurane
- Promethazine
- Miconazole
- Vernakalant
- Dalfampridine
- Isavuconazole
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MAP2K1 |
mitogen-activated protein kinase kinase 1 |
- MAPK3 (ERK1) activation
- Frs2-mediated activation
- Signal transduction by L1
- Uptake and function of anthrax toxins
- RAF activation
- MAP2K and MAPK activation
- Negative feedback regulation of MAPK pathway
- MAP3K8 (TPL2)-dependent MAPK1/3 activation
- Signaling by moderate kinase activity BRAF mutants
- Signaling by high-kinase activity BRAF mutants
- Signaling by BRAF and RAF fusions
- Paradoxical activation of RAF signaling by kinase inactive BRAF
- Signaling downstream of RAS mutants
- Signaling by MAP2K mutants
- Signaling by RAF1 mutants
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- K-252a
- 5-Bromo-N-[(2S)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
- Cobimetinib
- Bosutinib
- (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide
- 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide
- PD-0325901
- N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine
- 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE
- Trametinib
- Selumetinib
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- Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
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MT-ND2 |
NADH dehydrogenase subunit 2 |
- Respiratory electron transport
- Complex I biogenesis
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- Leber optic atrophy; Leber hereditary optic atrophy (LHON)
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MYLK |
myosin light chain kinase |
- Smooth Muscle Contraction
- RHO GTPases activate PAKs
- RHO GTPases activate PAKs
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- Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
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NOS2 |
nitric oxide synthase 2 |
- ROS and RNS production in phagocytes
- Nitric oxide stimulates guanylate cyclase
- Interleukin-4 and Interleukin-13 signaling
- Peroxisomal protein import
- Peroxisomal protein import
- Inhibition of nitric oxide production
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- Arginine
- Citrulline
- Minocycline
- Miconazole
- Dexamethasone
- N,N-dimethylarginine
- 4R-Fluoro-N6-ethanimidoyl-L-lysine
- 3-Bromo-7-Nitroindazole
- N-[3-(aminomethyl)benzyl]acetamidine
- 7-Nitroindazole
- S-Ethylisothiourea
- Thiocoumarin
- N-omega-propyl-L-arginine
- 6-Nitroindazole
- N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine
- Imidazole
- N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide
- Thiocitrulline
- L-erythro-7,8-dihydrobiopterin
- 5-Nitroindazole
- KD7040
- Fenoxaprop-ethyl
- Pimagedine
- 5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE
- N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE
- 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile
- (2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine
- (3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine
- 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE
- (3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE
- 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE
- ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
- N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE
- ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
- N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE
- 1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE
- 4-(1H-IMIDAZOL-1-YL)PHENOL
- 1-[4-(AMINOMETHYL)BENZOYL]-5'-FLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLIN]-4'-AMINE
- Triflusal
- Levamlodipine
- Dipyrithione
- Dexamethasone acetate
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NPHS1 |
NPHS1 adhesion molecule, nephrin |
- Nephrin family interactions
- Nephrin family interactions
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- Nephrotic syndrome and focal segmental glomerulosclerosis
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NR3C1 |
nuclear receptor subfamily 3 group C member 1 |
- HSP90 chaperone cycle for steroid hormone receptors (SHR)
- Circadian Clock
- SUMOylation of intracellular receptors
- PTK6 Expression
- Regulation of RUNX2 expression and activity
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- Potential therapeutics for SARS
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- Flunisolide
- Diflorasone
- Alclometasone
- Medrysone
- Amcinonide
- Fluorometholone
- Megestrol acetate
- Levonorgestrel
- Beclomethasone dipropionate
- Progesterone
- Spironolactone
- Betamethasone
- Desoximetasone
- Fluticasone propionate
- Fluocinolone acetonide
- Ulobetasol
- Triamcinolone
- Prednisone
- Flumethasone
- Fludrocortisone
- Norethisterone
- Hydrocortisone
- Mometasone
- Hydrocortamate
- Mifepristone
- Clocortolone
- Flurandrenolide
- Prednisolone
- Loteprednol etabonate
- Rimexolone
- Methylprednisolone
- Clobetasol propionate
- Fluocinonide
- Prednicarbate
- Fluoxymesterone
- Budesonide
- Dexamethasone
- Desonide
- Cortisone acetate
- Paramethasone
- Drospirenone
- Ciclesonide
- Hexane-1,6-Diol
- Aldosterone
- ORG-34517
- Difluprednate
- Ulipristal
- Fluticasone furoate
- Tixocortol
- Difluocortolone
- Gestrinone
- Deflazacort
- Onapristone
- Cortivazol
- Clobetasone
- Fluticasone
- Mometasone furoate
- Hydrocortisone aceponate
- Hydrocortisone acetate
- Hydrocortisone butyrate
- Hydrocortisone cypionate
- Hydrocortisone phosphate
- Hydrocortisone probutate
- Hydrocortisone valerate
- Segesterone acetate
- Prednisolone phosphate
- Dexamethasone acetate
- Betamethasone phosphate
- Prednisolone acetate
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- 46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
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PDE6G |
phosphodiesterase 6G |
- Activation of the phototransduction cascade
- Activation of the phototransduction cascade
- Inactivation, recovery and regulation of the phototransduction cascade
- Ca2+ pathway
- Ca2+ pathway
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- Sildenafil
- Vardenafil
- 3-isobutyl-1-methyl-7H-xanthine
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- Retinitis pigmentosa (RP)
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PDGFRB |
platelet derived growth factor receptor beta |
- PIP3 activates AKT signaling
- Downstream signal transduction
- Signaling by PDGF
- Constitutive Signaling by Aberrant PI3K in Cancer
- RAF/MAP kinase cascade
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
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- Becaplermin
- Sorafenib
- Imatinib
- Dasatinib
- Sunitinib
- XL999
- XL820
- Pazopanib
- Midostaurin
- Regorafenib
- Nintedanib
- Polaprezinc
- Trapidil
- Foreskin fibroblast (neonatal)
- Fostamatinib
- Erdafitinib
- Pexidartinib
- Ripretinib
- Pralsetinib
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PIP5K1C |
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma |
- Synthesis of PIPs at the plasma membrane
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- Clathrin-mediated endocytosis
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- Lethal congenital contractural syndrome (LCCS)
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PKD1 |
polycystin 1, transient receptor potential channel interacting |
- VxPx cargo-targeting to cilium
- VxPx cargo-targeting to cilium
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- Polycystic kidney disease
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PTPN2 |
protein tyrosine phosphatase non-receptor type 2 |
- Negative regulation of MET activity
- Interleukin-37 signaling
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