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TASOR |
transcription activation suppressor |
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TBP |
TATA-box binding protein |
- HIV Transcription Initiation
- RNA Polymerase II HIV Promoter Escape
- Transcription of the HIV genome
- SIRT1 negatively regulates rRNA expression
- NoRC negatively regulates rRNA expression
- B-WICH complex positively regulates rRNA expression
- RNA Polymerase II Pre-transcription Events
- Regulation of TP53 Activity through Phosphorylation
- RNA polymerase II transcribes snRNA genes
- RNA polymerase II transcribes snRNA genes
- RNA Polymerase I Transcription Initiation
- RNA Polymerase I Transcription Initiation
- RNA Polymerase I Promoter Escape
- RNA Polymerase II Promoter Escape
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase I Transcription Termination
- RNA Polymerase III Abortive And Retractive Initiation
- RNA Polymerase II Transcription Initiation
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- RNA Polymerase III Transcription Initiation From Type 1 Promoter
- RNA Polymerase III Transcription Initiation From Type 1 Promoter
- RNA Polymerase III Transcription Initiation From Type 2 Promoter
- RNA Polymerase III Transcription Initiation From Type 2 Promoter
- RNA Polymerase III Transcription Initiation From Type 3 Promoter
- RNA Polymerase III Transcription Initiation From Type 3 Promoter
- Estrogen-dependent gene expression
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- Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
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TFAP2A |
transcription factor AP-2 alpha |
- Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
- Negative regulation of activity of TFAP2 (AP-2) family transcription factors
- Negative regulation of activity of TFAP2 (AP-2) family transcription factors
- TFAP2 (AP-2) family regulates transcription of other transcription factors
- Activation of the TFAP2 (AP-2) family of transcription factors
- TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
- TFAP2 (AP-2) family regulates transcription of cell cycle factors
- TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
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- Branchiooculofacial syndrome (BOFS)
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TGM2 |
transglutaminase 2 |
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- Guanosine-5'-Diphosphate
- Hexylresorcinol
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THOC1 |
THO complex 1 |
- Transport of Mature mRNA derived from an Intron-Containing Transcript
- mRNA 3'-end processing
- RNA Polymerase II Transcription Termination
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TMPO |
thymopoietin |
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TOP2A |
DNA topoisomerase II alpha |
- Transcription of E2F targets under negative control by DREAM complex
- SUMOylation of DNA replication proteins
- SUMOylation of DNA replication proteins
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- Moxifloxacin
- Amsacrine
- Dexrazoxane
- Valrubicin
- Teniposide
- Epirubicin
- Enoxacin
- Pefloxacin
- Ciprofloxacin
- Trovafloxacin
- Daunorubicin
- Etoposide
- Dactinomycin
- Lomefloxacin
- Doxorubicin
- Norfloxacin
- Ofloxacin
- Idarubicin
- Podofilox
- Mitoxantrone
- Sparfloxacin
- Genistein
- Fleroxacin
- Lucanthone
- Banoxantrone
- SP1049C
- Amonafide
- Elsamitrucin
- 13-deoxydoxorubicin
- RTA 744
- Aldoxorubicin
- ZEN-012
- Amrubicin
- Becatecarin
- Annamycin
- Declopramide
- Finafloxacin
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TP53 |
tumor protein p53 |
- Activation of NOXA and translocation to mitochondria
- Activation of PUMA and translocation to mitochondria
- Pre-NOTCH Transcription and Translation
- Oxidative Stress Induced Senescence
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
- Oncogene Induced Senescence
- DNA Damage/Telomere Stress Induced Senescence
- SUMOylation of transcription factors
- Autodegradation of the E3 ubiquitin ligase COP1
- Association of TriC/CCT with target proteins during biosynthesis
- TP53 Regulates Metabolic Genes
- Ub-specific processing proteases
- Ovarian tumor domain proteases
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Interleukin-4 and Interleukin-13 signaling
- TP53 Regulates Transcription of DNA Repair Genes
- TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
- TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
- TP53 Regulates Transcription of Caspase Activators and Caspases
- TP53 Regulates Transcription of Death Receptors and Ligands
- TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
- TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
- TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
- Regulation of TP53 Expression
- Regulation of TP53 Activity through Phosphorylation
- Regulation of TP53 Degradation
- Regulation of TP53 Activity through Acetylation
- Regulation of TP53 Activity through Association with Co-factors
- Regulation of TP53 Activity through Methylation
- PI5P Regulates TP53 Acetylation
- G2/M DNA damage checkpoint
- G2/M Checkpoints
- Stabilization of p53
- Transcriptional activation of cell cycle inhibitor p21
- The role of GTSE1 in G2/M progression after G2 checkpoint
- Transcriptional Regulation by VENTX
- RUNX3 regulates CDKN1A transcription
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- Factors involved in megakaryocyte development and platelet production
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- Acetylsalicylic acid
- Zinc
- Triethyl phosphate
- AZD 3355
- 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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- Osteosarcoma
- Adrenal carcinoma
- Thyroid cancer
- Breast cancer
- Basal cell carcinoma
- Malignant melanoma
- Pancreatic cancer
- Gastric cancer
- Malignant pleural mesothelioma
- Non-small cell lung cancer
- Esophageal cancer
- Oral cancer
- Multiple myeloma
- Small cell lung cancer
- Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL)
- Glioma
- Squamous cell carcinoma
- Kaposi's sarcoma
- Cholangiocarcinoma
- Gallbladder cancer
- Cancer of the anal canal
- Hepatocellular carcinoma
- Choriocarcinoma
- Vulvar cancer
- Choroid plexus papilloma
- Burkitt lymphoma
- Adult T-cell leukemia
- Hairy-cell leukemia
- Bladder cancer
- Chronic lymphocytic leukemia (CLL)
- Penile cancer
- Endometrial Cancer
- Ovarian cancer
- Colorectal cancer
- Laryngeal cancer
- Chronic myeloid leukemia (CML)
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TRAP1 |
TNF receptor associated protein 1 |
- Respiratory electron transport
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TRIM27 |
tripartite motif containing 27 |
- SUMOylation of ubiquitinylation proteins
- Regulation of PTEN stability and activity
- Suppression of apoptosis
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TRIP11 |
thyroid hormone receptor interactor 11 |
- Intraflagellar transport
- Intra-Golgi traffic
- Signaling by FLT3 fusion proteins
- Signaling by FLT3 fusion proteins
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TRMO |
tRNA methyltransferase O |
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UBE2I |
ubiquitin conjugating enzyme E2 I |
- Meiotic synapsis
- Vitamin D (calciferol) metabolism
- SUMO is transferred from E1 to E2 (UBE2I, UBC9)
- SUMO is transferred from E1 to E2 (UBE2I, UBC9)
- SUMOylation of DNA damage response and repair proteins
- SUMO E3 ligases SUMOylate target proteins
- SUMOylation of transcription factors
- SUMOylation of transcription factors
- SUMOylation of ubiquitinylation proteins
- SUMOylation of transcription cofactors
- SUMOylation of transcription cofactors
- SUMOylation of SUMOylation proteins
- SUMOylation of intracellular receptors
- SUMOylation of intracellular receptors
- SUMOylation of chromatin organization proteins
- SUMOylation of chromatin organization proteins
- SUMOylation of RNA binding proteins
- SUMOylation of DNA replication proteins
- SUMOylation of DNA replication proteins
- SUMOylation of DNA methylation proteins
- SUMOylation of DNA methylation proteins
- SUMOylation of immune response proteins
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Processing of DNA double-strand break ends
- Formation of Incision Complex in GG-NER
- Negative regulation of activity of TFAP2 (AP-2) family transcription factors
- Negative regulation of activity of TFAP2 (AP-2) family transcription factors
- Postmitotic nuclear pore complex (NPC) reformation
- Maturation of nucleoprotein
- Maturation of nucleoprotein
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UBTF |
upstream binding transcription factor |
- NoRC negatively regulates rRNA expression
- RNA Polymerase I Promoter Opening
- RNA Polymerase I Transcription Initiation
- RNA Polymerase I Promoter Escape
- RNA Polymerase I Transcription Termination
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USP4 |
ubiquitin specific peptidase 4 |
- TNFR1-induced proapoptotic signaling
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- Ub-specific processing proteases
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USP7 |
ubiquitin specific peptidase 7 |
- Ub-specific processing proteases
- Formation of TC-NER Pre-Incision Complex
- Transcription-Coupled Nucleotide Excision Repair (TC-NER)
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- Regulation of TP53 Degradation
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Regulation of PTEN localization
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VDR |
vitamin D receptor |
- Vitamin D (calciferol) metabolism
- Nuclear Receptor transcription pathway
- SUMOylation of intracellular receptors
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- Calcitriol
- Calcifediol
- Ergocalciferol
- Cholecalciferol
- Paricalcitol
- Dihydrotachysterol
- Alfacalcidol
- Calcipotriol
- Lexacalcitol
- Seocalcitol
- Cholesterol
- Inecalcitol
- Becocalcidiol
- CTA018
- Eldecalcitol
- Elocalcitol
- Doxercalciferol
- (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol
- 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)
- Vitamin D
- Curcumin
- Curcumin sulfate
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- Tuberculosis
- Localized autosomal recessive hypotrichosis
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XPA |
XPA, DNA damage recognition and repair factor |
- Formation of Incision Complex in GG-NER
- Dual Incision in GG-NER
- Formation of TC-NER Pre-Incision Complex
- Dual incision in TC-NER
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- Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
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ZBTB16 |
zinc finger and BTB domain containing 16 |
- Neddylation
- Antigen processing: Ubiquitination & Proteasome degradation
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- Skeletal defects, genital hypoplasia, and mental retardation
- Acute myeloid leukemia (AML)
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