Search Results for: RASSF1

75 interactions involving RASSF1 - Ras association domain family member 1 found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
MAP2K6 mitogen-activated protein kinase kinase 6
  • NOD1/2 Signaling Pathway
  • Oxidative Stress Induced Senescence
  • activated TAK1 mediates p38 MAPK activation
  • Myogenesis
  • PI5P Regulates TP53 Acetylation
  • Interleukin-1 signaling
  • Fostamatinib
CDKN2B cyclin dependent kinase inhibitor 2B
  • SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
  • Oxidative Stress Induced Senescence
  • Senescence-Associated Secretory Phenotype (SASP)
  • Oncogene Induced Senescence
  • Cyclin D associated events in G1
  • Malignant pleural mesothelioma
  • Osteosarcoma
  • Type II diabetes mellitus
TSC1 TSC complex subunit 1
  • Macroautophagy
  • Inhibition of TSC complex formation by PKB
  • Energy dependent regulation of mTOR by LKB1-AMPK
  • TP53 Regulates Metabolic Genes
  • TBC/RABGAPs
  • Lymphangioleiomyomatosis (LAM)
  • Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GRM1 glutamate metabotropic receptor 1
  • G alpha (q) signalling events
  • Class C/3 (Metabotropic glutamate/pheromone receptors)
  • Neurexins and neuroligins
  • Neurexins and neuroligins
  • Glutamic acid
  • (S)-alpha-methyl-4-carboxyphenylglycine
PRKDC protein kinase, DNA-activated, catalytic subunit
  • Cytosolic sensors of pathogen-associated DNA
  • IRF3-mediated induction of type I IFN
  • Nonhomologous End-Joining (NHEJ)
  • E3 ubiquitin ligases ubiquitinate target proteins
  • Caffeine
  • SF1126
STK11 serine/threonine kinase 11
  • AMPK inhibits chREBP transcriptional activation activity
  • Energy dependent regulation of mTOR by LKB1-AMPK
  • Regulation of TP53 Activity through Phosphorylation
  • FOXO-mediated transcription of cell death genes
  • Peutz-Jeghers syndrome
  • Pancreatic cancer
XPA XPA, DNA damage recognition and repair factor
  • Formation of Incision Complex in GG-NER
  • Dual Incision in GG-NER
  • Formation of TC-NER Pre-Incision Complex
  • Dual incision in TC-NER
  • Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
ATP2B4 ATPase plasma membrane Ca2+ transporting 4
  • Reduction of cytosolic Ca++ levels
  • Ion homeostasis
  • Ion transport by P-type ATPases
  • Halothane
  • Desflurane
ATRX ATRX chromatin remodeler
  • Inhibition of DNA recombination at telomere
  • Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations
  • Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations
  • Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
  • Thalassemia; Alpha thalassemia; Beta thalassemia; Alpha thalassemia, X-linked (ATRX)
  • Non-syndromic X-linked mental retardation
  • 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
CCND2 cyclin D2
  • Cyclin D associated events in G1
  • Regulation of RUNX1 Expression and Activity
  • Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
  • Testicular cancer
IGFBP5 insulin like growth factor binding protein 5
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • Post-translational protein phosphorylation
KCNE3 potassium voltage-gated channel subfamily E regulatory subunit 3
  • Phase 3 - rapid repolarisation
  • Phase 2 - plateau phase
  • Enflurane
  • Promethazine
  • Miconazole
  • Brugada syndrome (BRS)
KDELR2 KDEL endoplasmic reticulum protein retention receptor 2
  • COPI-mediated anterograde transport
  • COPI-dependent Golgi-to-ER retrograde traffic
MAP2K3 mitogen-activated protein kinase kinase 3
  • Oxidative Stress Induced Senescence
  • activated TAK1 mediates p38 MAPK activation
  • Fostamatinib
NF2 neurofibromin 2
  • Regulation of actin dynamics for phagocytic cup formation
  • RHO GTPases activate PAKs
  • Malignant pleural mesothelioma
  • Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
RHOU ras homolog family member U
  • Rho GTPase cycle
  • Interleukin-4 and Interleukin-13 signaling
SUV39H1 suppressor of variegation 3-9 homolog 1
  • PKMTs methylate histone lysines
  • SIRT1 negatively regulates rRNA expression
TEAD2 TEA domain transcription factor 2
  • YAP1- and WWTR1 (TAZ)-stimulated gene expression
  • RUNX3 regulates YAP1-mediated transcription
TERT telomerase reverse transcriptase
  • Telomere Extension By Telomerase
  • Formation of the beta-catenin:TCF transactivating complex
  • Zidovudine
  • Grn163l
  • Tertomotide
  • Cri du chat syndrome; Cat cry syndrome; Chromosme 5p deletion syndrome
LATS2 large tumor suppressor kinase 2
  • Signaling by Hippo

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